From jamming to collective cell migration through a boundary induced transition

Oleksandr Chepizhko; Maria Chiara Lionetti; Chiara Malinverno; Costanza Giampietro; Giorgio Scita; Stefano Zapperi; Caterina A.M. La Porta

doi:10.1039/c8sm00128f

From jamming to collective cell migration through a boundary induced transition

Oleksandr Chepizhko, Maria Chiara Lionetti, Chiara Malinverno, Costanza Giampietro, Giorgio Scita, Stefano Zapperi^*, Caterina A.M. La Porta

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Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

30 Sitaatiot (Scopus)

Abstrakti

Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.

Alkuperäiskieli	Englanti
Sivut	3774-3782
Sivumäärä	9
Julkaisu	Soft Matter
Vuosikerta	14
Numero	19
DOI - pysyväislinkit	https://doi.org/10.1039/c8sm00128f
Tila	Julkaistu - 1 tammik. 2018
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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10.1039/c8sm00128f

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Melu ja fluktuaatiot materiaaleissa
Jana, P. (Projektin jäsen), Koivisto, J. (Projektin jäsen), Alava, M. (Vastuullinen tutkija), Zapperi, S. (Projektin jäsen), Lehtinen, A. (Projektin jäsen), Hanifpour, M. (Projektin jäsen), Korhonen, M. (Projektin jäsen), Salmenjoki, H. (Projektin jäsen) & Viitanen, L. (Projektin jäsen)
01/09/2014 → 31/12/2018
Projekti: Academy of Finland: Other research funding

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title = "From jamming to collective cell migration through a boundary induced transition",

abstract = "Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.",

author = "Oleksandr Chepizhko and Lionetti, {Maria Chiara} and Chiara Malinverno and Costanza Giampietro and Giorgio Scita and Stefano Zapperi and {La Porta}, {Caterina A.M.}",

year = "2018",

month = jan,

day = "1",

doi = "10.1039/c8sm00128f",

language = "English",

volume = "14",

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journal = "Soft Matter",

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TY - JOUR

T1 - From jamming to collective cell migration through a boundary induced transition

AU - Chepizhko, Oleksandr

AU - Lionetti, Maria Chiara

AU - Malinverno, Chiara

AU - Giampietro, Costanza

AU - Scita, Giorgio

AU - Zapperi, Stefano

AU - La Porta, Caterina A.M.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.

AB - Cell monolayers provide an interesting example of active matter, exhibiting a phase transition from flowing to jammed states as they age. Here we report experiments and numerical simulations illustrating how a jammed cellular layer rapidly reverts to a flowing state after a wound. Quantitative comparison between experiments and simulations shows that cells change their self-propulsion and alignment strength so that the system crosses a phase transition line, which we characterize by finite-size scaling in an active particle model. This wound-induced unjamming transition is found to occur generically in epithelial, endothelial and cancer cells.

UR - http://www.scopus.com/inward/record.url?scp=85047453060&partnerID=8YFLogxK

U2 - 10.1039/c8sm00128f

DO - 10.1039/c8sm00128f

M3 - Article

AN - SCOPUS:85047453060

SN - 1744-683X

VL - 14

SP - 3774

EP - 3782

JO - Soft Matter

JF - Soft Matter

IS - 19

ER -

From jamming to collective cell migration through a boundary induced transition

Abstrakti

YK:n kestävän kehityksen tavoitteet

Pääsy asiakirjaan

Muut tiedostot ja linkit

Sormenjälki

Projektit

Melu ja fluktuaatiot materiaaleissa

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