Fate, Behavior, and Biophysical Modeling of Nanoparticles in Living Systems

Tutkimustuotos: Artikkeli kirjassa/konferenssijulkaisussavertaisarvioitu

Tutkijat

Organisaatiot

  • Clemson University
  • Monash University

Kuvaus

This chapter serves as an example on how such physical approaches may shed light on understanding of the fate and behavior of nanoparticles in the aqueous phase and in living systems. It discusses the solubility of carbon-based nanomaterials, namely, carbon nanotubes, fullerenes, graphene, and graphene oxides, in the presence of natural amphiphiles of gallic acid, natural organic matter, cellulose, fatty acids, and peptides that are building blocks of the biosphere. The chapter shows hydrogen bond formation between a fullerene derivative C60(OH)20, or "fullerol", and nucleic acids and Taq DNA polymerase; the latter is a machinery responsible for gene amplification in vitro and may be regarded as a model system for evauating the impact of nanoparticles on enzymatic activities in vivo. It describes how pristine fullerene and fullerol reach their different energetic minima within a lipid bilayer, and extend results from this study to the interpretations of nanotoxicity for both mammalian and plant cells.

Yksityiskohdat

AlkuperäiskieliEnglanti
OtsikkoEngineered Nanoparticles and the Environment: Biophysicochemical Processes and Toxicity
TilaJulkaistu - 19 syyskuuta 2016
OKM-julkaisutyyppiA3 Kirjan osa tai toinen tutkimuskirja

ID: 12863275