Epoxy resin monomers with reduced skin sensitizing potency

Niamh M. O'Boyle, Ida B. Niklasson, Ali R. Tehrani-Bagha, Tamara Delaine, Krister Holmberg, Kristina Luthman, Ann Therese Karlberg*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

6 Sitaatiot (Scopus)

Abstrakti

Epoxy resin monomers (ERMs), especially diglycidyl ethers of bisphenol A and F (DGEBA and DGEBF), are extensively used as building blocks for thermosetting polymers. However, they are known to commonly cause skin allergy. This research describes a number of alternative ERMs, designed with the aim of reducing the skin sensitizing potency while maintaining the ability to form thermosetting polymers. The compounds were designed, synthesized, and assessed for sensitizing potency using the in vivo murine local lymph node assay (LLNA). All six epoxy resin monomers had decreased sensitizing potencies compared to those of DGEBA and DGEBF. With respect to the LLNA EC3 value, the best of the alternative monomers had a value approximately 2.5 times higher than those of DGEBA and DGEBF. The diepoxides were reacted with triethylenetetramine, and the polymers formed were tested for technical applicability using thermogravimetric analysis and differential scanning calorimetry. Four out of the six alternative ERMs gave polymers with a thermal stability comparable to that obtained with DGEBA and DGEBF. The use of improved epoxy resin monomers with less skin sensitizing effects is a direct way to tackle the problem of contact allergy to epoxy resin systems, particularly in occupational settings, resulting in a reduction in the incidence of allergic contact dermatitis.

AlkuperäiskieliEnglanti
Sivut1002-1010
Sivumäärä9
JulkaisuCHEMICAL RESEARCH IN TOXICOLOGY
Vuosikerta27
Numero6
DOI - pysyväislinkit
TilaJulkaistu - 16 kesäkuuta 2014
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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