Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

Tutkimustuotos: Lehtiartikkeli

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Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release. / Dong, Yujiao; Paukkonen, Heli; Fang, Wenwen; Kontturi, Eero; Laaksonen, Timo; Laaksonen, Päivi.

julkaisussa: International Journal of Pharmaceutics, Vuosikerta 548, Nro 1, 05.09.2018, s. 113-119.

Tutkimustuotos: Lehtiartikkeli

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Dong, Yujiao ; Paukkonen, Heli ; Fang, Wenwen ; Kontturi, Eero ; Laaksonen, Timo ; Laaksonen, Päivi. / Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release. Julkaisussa: International Journal of Pharmaceutics. 2018 ; Vuosikerta 548, Nro 1. Sivut 113-119.

Bibtex - Lataa

@article{7c84267a571e42e9b5f9a2babc252ddc,
title = "Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release",
abstract = "Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell™ cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices. The viscosity as well as the lignin-content played a role in the release dynamics of the drugs. Microcrystalline AaltoCell™ was proven as high-performing material for diffusion controlled release of the chosen model compounds and can be seen as a safe and economical alternative for novel matrix materials such as nanocellulose or cellulose derivatives.",
keywords = "Cellulose hydrogel, Controlled release, Diffusion-limited release, Microcrystalline cellulose",
author = "Yujiao Dong and Heli Paukkonen and Wenwen Fang and Eero Kontturi and Timo Laaksonen and P{\"a}ivi Laaksonen",
year = "2018",
month = "9",
day = "5",
doi = "10.1016/j.ijpharm.2018.06.022",
language = "English",
volume = "548",
pages = "113--119",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1",

}

RIS - Lataa

TY - JOUR

T1 - Entangled and colloidally stable microcrystalline cellulose matrices in controlled drug release

AU - Dong, Yujiao

AU - Paukkonen, Heli

AU - Fang, Wenwen

AU - Kontturi, Eero

AU - Laaksonen, Timo

AU - Laaksonen, Päivi

PY - 2018/9/5

Y1 - 2018/9/5

N2 - Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell™ cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices. The viscosity as well as the lignin-content played a role in the release dynamics of the drugs. Microcrystalline AaltoCell™ was proven as high-performing material for diffusion controlled release of the chosen model compounds and can be seen as a safe and economical alternative for novel matrix materials such as nanocellulose or cellulose derivatives.

AB - Drug release from a new type of matrix material consisting of partially fibrillated microcrystalline cellulose was investigated. A mechanical treatment of novel AaltoCell™ cellulose microcrystals caused partial opening of the nanofibrillary structure of the cellulose particles and entanglement of individual particles led into formation of an elastic network of microcrystalline cellulose. The rheological properties of the stable hydrogel-like materials were characterised by shear rheometry. Model compounds metronidazole and lysozyme were successfully employed in drug release experiments carried out by delignified (bleached) and lignin-containing matrices. The viscosity as well as the lignin-content played a role in the release dynamics of the drugs. Microcrystalline AaltoCell™ was proven as high-performing material for diffusion controlled release of the chosen model compounds and can be seen as a safe and economical alternative for novel matrix materials such as nanocellulose or cellulose derivatives.

KW - Cellulose hydrogel

KW - Controlled release

KW - Diffusion-limited release

KW - Microcrystalline cellulose

UR - http://www.scopus.com/inward/record.url?scp=85049349070&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2018.06.022

DO - 10.1016/j.ijpharm.2018.06.022

M3 - Article

VL - 548

SP - 113

EP - 119

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -

ID: 28319670