Enhanced polymer capture speed and extended translocation time in pressure-solvation traps

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Enhanced polymer capture speed and extended translocation time in pressure-solvation traps. / Buyukdagli, Sahin.

julkaisussa: Physical Review E, Vuosikerta 97, Nro 6, 062406, 11.06.2018, s. 1-13.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

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Buyukdagli, Sahin. / Enhanced polymer capture speed and extended translocation time in pressure-solvation traps. Julkaisussa: Physical Review E. 2018 ; Vuosikerta 97, Nro 6. Sivut 1-13.

Bibtex - Lataa

@article{9b2c52243e9a410f804f367168b21d5c,
title = "Enhanced polymer capture speed and extended translocation time in pressure-solvation traps",
abstract = "The efficiency of nanopore-based biosequencing techniques requires fast anionic polymer capture by like-charged pores followed by a prolonged translocation process. We show that this condition can be achieved by setting a pressure-solvation trap. Polyvalent cation addition to the KCl solution triggers the like-charge polymer-pore attraction. The attraction speeds-up the pressure-driven polymer capture but also traps the molecule at the pore exit, reducing the polymer capture time and extending the polymer escape time by several orders of magnitude. By direct comparison with translocation experiments [D. P. Hoogerheide, ACS Nano 8, 7384 (2014)1936-085110.1021/nn5025829], we characterize as well the electrohydrodynamics of polymers transport in pressure-voltage traps. We derive scaling laws that can accurately reproduce the pressure dependence of the experimentally measured polymer translocation velocity and time. We also find that during polymer capture, the electrostatic barrier on the translocating molecule slows down the liquid flow. This prediction identifies the streaming current measurement as a potential way to probe electrostatic polymer-pore interactions.",
author = "Sahin Buyukdagli",
year = "2018",
month = "6",
day = "11",
doi = "10.1103/PhysRevE.97.062406",
language = "English",
volume = "97",
pages = "1--13",
journal = "Physical Review E",
issn = "2470-0045",
publisher = "American Physical Society",
number = "6",

}

RIS - Lataa

TY - JOUR

T1 - Enhanced polymer capture speed and extended translocation time in pressure-solvation traps

AU - Buyukdagli, Sahin

PY - 2018/6/11

Y1 - 2018/6/11

N2 - The efficiency of nanopore-based biosequencing techniques requires fast anionic polymer capture by like-charged pores followed by a prolonged translocation process. We show that this condition can be achieved by setting a pressure-solvation trap. Polyvalent cation addition to the KCl solution triggers the like-charge polymer-pore attraction. The attraction speeds-up the pressure-driven polymer capture but also traps the molecule at the pore exit, reducing the polymer capture time and extending the polymer escape time by several orders of magnitude. By direct comparison with translocation experiments [D. P. Hoogerheide, ACS Nano 8, 7384 (2014)1936-085110.1021/nn5025829], we characterize as well the electrohydrodynamics of polymers transport in pressure-voltage traps. We derive scaling laws that can accurately reproduce the pressure dependence of the experimentally measured polymer translocation velocity and time. We also find that during polymer capture, the electrostatic barrier on the translocating molecule slows down the liquid flow. This prediction identifies the streaming current measurement as a potential way to probe electrostatic polymer-pore interactions.

AB - The efficiency of nanopore-based biosequencing techniques requires fast anionic polymer capture by like-charged pores followed by a prolonged translocation process. We show that this condition can be achieved by setting a pressure-solvation trap. Polyvalent cation addition to the KCl solution triggers the like-charge polymer-pore attraction. The attraction speeds-up the pressure-driven polymer capture but also traps the molecule at the pore exit, reducing the polymer capture time and extending the polymer escape time by several orders of magnitude. By direct comparison with translocation experiments [D. P. Hoogerheide, ACS Nano 8, 7384 (2014)1936-085110.1021/nn5025829], we characterize as well the electrohydrodynamics of polymers transport in pressure-voltage traps. We derive scaling laws that can accurately reproduce the pressure dependence of the experimentally measured polymer translocation velocity and time. We also find that during polymer capture, the electrostatic barrier on the translocating molecule slows down the liquid flow. This prediction identifies the streaming current measurement as a potential way to probe electrostatic polymer-pore interactions.

UR - http://www.scopus.com/inward/record.url?scp=85048472022&partnerID=8YFLogxK

U2 - 10.1103/PhysRevE.97.062406

DO - 10.1103/PhysRevE.97.062406

M3 - Article

VL - 97

SP - 1

EP - 13

JO - Physical Review E

JF - Physical Review E

SN - 2470-0045

IS - 6

M1 - 062406

ER -

ID: 26409062