Engineered protein cages for selective heparin encapsulation

Salla Välimäki; Qing Liu; Lise Schoonen; Daan F. M. Vervoort; Nonappa Nonappa; Veikko Linko; Roeland J. M. Nolte; Jan C. M. van Hest; Mauri Kostiainen

doi:10.1039/D0TB02541K

Engineered protein cages for selective heparin encapsulation

Salla Välimäki, Qing Liu, Lise Schoonen, Daan F. M. Vervoort, Nonappa Nonappa, Veikko Linko, Roeland J. M. Nolte, Jan C. M. van Hest, Mauri Kostiainen

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

37 Lataukset (Pure)

Abstrakti

A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

Alkuperäiskieli	Englanti
Sivut	1272-1276
Sivumäärä	5
Julkaisu	Journal of Materials Chemistry B
Vuosikerta	9
Numero	5
DOI - pysyväislinkit	https://doi.org/10.1039/D0TB02541K
Tila	Julkaistu - 7 helmik. 2021
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

Pääsy asiakirjaan

10.1039/D0TB02541KLisenssi: CC BY-NC

d0tb02541kFinal published version, 3,77 MBLisenssi: CC BY-NC

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Koko teksti

SYNVIRO: Polyelektrolyyttien Enkapsulointi Synteettisen Virologian Keinoin (SYNVIRO)
Kostiainen, M., Ahmed, A., Anaya Plaza, E., Liu, Q., Julin, S., Välimäki, S. & Korpi, A.
01/09/2017 → 31/08/2021
Projekti: Academy of Finland: Other research funding
Proteiinihäkeillä suunnattu itsejärjestyminen nanomateriaaleissa
Kostiainen, M., Korpi, A., Damania, A., Liljeström, V. & Ora, A.
01/09/2016 → 31/08/2018
Projekti: Academy of Finland: Other research funding

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Siteeraa tätä

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title = "Engineered protein cages for selective heparin encapsulation",

abstract = "A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.",

author = "Salla V{\"a}lim{\"a}ki and Qing Liu and Lise Schoonen and {F. M. Vervoort}, Daan and Nonappa Nonappa and Veikko Linko and Nolte, {Roeland J. M.} and {C. M. van Hest}, Jan and Mauri Kostiainen",

year = "2021",

month = feb,

day = "7",

doi = "10.1039/D0TB02541K",

language = "English",

volume = "9",

pages = "1272--1276",

journal = "JOURNAL OF MATERIALS CHEMISTRY. B",

issn = "2050-750X",

publisher = "Royal Society of Chemistry",

number = "5",

}

TY - JOUR

T1 - Engineered protein cages for selective heparin encapsulation

AU - Välimäki, Salla

AU - Liu, Qing

AU - Schoonen, Lise

AU - F. M. Vervoort, Daan

AU - Nonappa, Nonappa

AU - Linko, Veikko

AU - Nolte, Roeland J. M.

AU - C. M. van Hest, Jan

AU - Kostiainen, Mauri

PY - 2021/2/7

Y1 - 2021/2/7

N2 - A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

AB - A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

U2 - 10.1039/D0TB02541K

DO - 10.1039/D0TB02541K

M3 - Article

VL - 9

SP - 1272

EP - 1276

JO - JOURNAL OF MATERIALS CHEMISTRY. B

JF - JOURNAL OF MATERIALS CHEMISTRY. B

SN - 2050-750X

IS - 5

ER -

Engineered protein cages for selective heparin encapsulation

Abstrakti

Pääsy asiakirjaan

OpenUrl-saatavuus

Sormenjälki

Projektit

SYNVIRO: Polyelektrolyyttien Enkapsulointi Synteettisen Virologian Keinoin (SYNVIRO)

Proteiinihäkeillä suunnattu itsejärjestyminen nanomateriaaleissa

Laitteet

Biotalousinfrastruktuuri

OtaNano

OtaNano Nanomikroskopiakeskus

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