Effect of Surface Modification on the Pulmonary and Systemic Toxicity of Cellulose Nanofibrils

Kukka Aimonen, Mira Hartikainen, Monireh Imani, Satu Suhonen, Gerard Vales, Carlos Moreno, Hanna Saarelainen, Kirsi Siivola, Esa Vanhala, Henrik Wolff, Orlando J. Rojas, Hannu Norppa, Julia Catalan*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

Abstrakti

Cellulose nanofibrils (CNFs) have emerged as sustainable options for a wide range of applications. However, the high aspect ratio and biopersistence of CNFs raise concerns about potential health effects. Here, we evaluated the in vivo pulmonary and systemic toxicity of unmodified (U-CNF), carboxymethylated (C-CNF), and TEMPO (2,2,6,6-tetramethyl-piperidin-1-oxyl)-oxidized (T-CNF) CNFs, fibrillated in the same way and administered to mice by repeated (3x) pharyngeal aspiration (14, 28, and 56 mu g/ mouse/aspiration). Toxic effects were assessed up to 90 days after the last administration. Some mice were treated with T-CNF samples spiked with lipopolysaccharide (LPS; 0.02- 50 ng/mouse/aspiration) to assess the role of endotoxin contamination. The CNFs induced an acute infammatory reaction that subsided within 90 days, except for T-CNF. At 90 days post-administration, an increased DNA damage was observed in bronchoalveolar lavage and hepatic cells after exposure to T-CNF and C-CNF, respectively. Besides, LPS contamination dose-dependently increased the hepatic genotoxic effects of T-CNF.

AlkuperäiskieliEnglanti
Sivut2752–2766
Sivumäärä15
JulkaisuBiomacromolecules
Vuosikerta23
Numero7
Varhainen verkossa julkaisun päivämäärä9 kesäk. 2022
DOI - pysyväislinkit
TilaJulkaistu - 11 heinäk. 2022
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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