Effect of serum dilution fluids on the wear of unirradiated and high dose gamma-irradiated, vitamin E stabilized UHMWPE

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Effect of serum dilution fluids on the wear of unirradiated and high dose gamma-irradiated, vitamin E stabilized UHMWPE. / Saikko, Vesa.

julkaisussa: Wear, Vuosikerta 430-431, 15.07.2019, s. 76-80.

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@article{aa48e854079246659adcace6d41dcd77,
title = "Effect of serum dilution fluids on the wear of unirradiated and high dose gamma-irradiated, vitamin E stabilized UHMWPE",
abstract = "In orthopaedic tribology, the ISO 14242-1 standard recommends that the serum lubricant is diluted with deionized water (DW). Sometimes, phosphate buffered saline (PBS) is used instead for the dilution. Noncyclic, multidirectional pin-on-disk tests showed that the dilution of alpha calf serum with PBS or phosphate buffer resulted in a 5–40-fold decrease in the wear factor of unirradiated and of vitamin E stabilized, highly crosslinked ultrahigh molecular weight polyethylene (UHMWPE) compared with DW dilution. It appears that the phosphates were mainly responsible for this phenomenon. PBS dilution may result in a substantial underestimation of clinical wear. With 1:1 DW dilution, the mean wear factor of highly crosslinked UHMWPE was 5.7-fold lower than that of unirradiated UHMWPE.",
keywords = "Biomedical devices, Lubrication environment, Noncyclic pin-on-disk, UHMWPE",
author = "Vesa Saikko",
year = "2019",
month = "7",
day = "15",
doi = "10.1016/j.wear.2019.04.022",
language = "English",
volume = "430-431",
pages = "76--80",
journal = "Wear",
issn = "0043-1648",
publisher = "Elsevier BV",

}

RIS - Lataa

TY - JOUR

T1 - Effect of serum dilution fluids on the wear of unirradiated and high dose gamma-irradiated, vitamin E stabilized UHMWPE

AU - Saikko, Vesa

PY - 2019/7/15

Y1 - 2019/7/15

N2 - In orthopaedic tribology, the ISO 14242-1 standard recommends that the serum lubricant is diluted with deionized water (DW). Sometimes, phosphate buffered saline (PBS) is used instead for the dilution. Noncyclic, multidirectional pin-on-disk tests showed that the dilution of alpha calf serum with PBS or phosphate buffer resulted in a 5–40-fold decrease in the wear factor of unirradiated and of vitamin E stabilized, highly crosslinked ultrahigh molecular weight polyethylene (UHMWPE) compared with DW dilution. It appears that the phosphates were mainly responsible for this phenomenon. PBS dilution may result in a substantial underestimation of clinical wear. With 1:1 DW dilution, the mean wear factor of highly crosslinked UHMWPE was 5.7-fold lower than that of unirradiated UHMWPE.

AB - In orthopaedic tribology, the ISO 14242-1 standard recommends that the serum lubricant is diluted with deionized water (DW). Sometimes, phosphate buffered saline (PBS) is used instead for the dilution. Noncyclic, multidirectional pin-on-disk tests showed that the dilution of alpha calf serum with PBS or phosphate buffer resulted in a 5–40-fold decrease in the wear factor of unirradiated and of vitamin E stabilized, highly crosslinked ultrahigh molecular weight polyethylene (UHMWPE) compared with DW dilution. It appears that the phosphates were mainly responsible for this phenomenon. PBS dilution may result in a substantial underestimation of clinical wear. With 1:1 DW dilution, the mean wear factor of highly crosslinked UHMWPE was 5.7-fold lower than that of unirradiated UHMWPE.

KW - Biomedical devices

KW - Lubrication environment

KW - Noncyclic pin-on-disk

KW - UHMWPE

UR - http://www.scopus.com/inward/record.url?scp=85064634757&partnerID=8YFLogxK

U2 - 10.1016/j.wear.2019.04.022

DO - 10.1016/j.wear.2019.04.022

M3 - Article

VL - 430-431

SP - 76

EP - 80

JO - Wear

JF - Wear

SN - 0043-1648

ER -

ID: 35320364