Dynamic optical contrast imaging (DOCI): System theory for rapid, wide-field, multispectral optical imaging using fluorescence lifetime contrast mechanism

Harrison Cheng*, Yao Xie, Peter Pellionisz, Aidan Pearigen, Khuzaima Rangwalla, Oscar Stafsudd, Zachary Taylor, Maie St John, Warren Grundfest

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Artikkeli kirjassa/konferenssijulkaisussaConference article in proceedingsScientificvertaisarvioitu

2 Sitaatiot (Scopus)
234 Lataukset (Pure)

Abstrakti

Dynamic Optical Contrast Imaging (DOCi) is an imaging technique that generates image contrast through ratiometric measurements of the autouflorescence decay rates of aggregate uorophores in tissue. This method enables better tissue characterization by utilizing wide-field signal integration, eliminating constraints of uniform illumination, and reducing time-intensive computations that are bottlenecks in the clinical translation of traditional fluorescence lifetime imaging. Previous works have demonstrated remarkable tissue contrast between tissue types in clinical human pilot studies [Otolaryngology-Head and Neck Surgery 157, 480 (2017)]. However, there are still challenges in the development of several subsystems, which results in existing works to use relative models. A comprehensive mathematical framework is presented to describe the contrast mechanism of the DOCi system to allow intraoperative quantitative imaging, which merits consideration for evaluation in measuring tissue characteristics in several important clinical settings.

AlkuperäiskieliEnglanti
OtsikkoMedical Imaging 2019
AlaotsikkoImage-Guided Procedures, Robotic Interventions, and Modeling
ToimittajatBaowei Fei, Cristian A. Linte
KustantajaSPIE
ISBN (elektroninen)9781510625495
DOI - pysyväislinkit
TilaJulkaistu - 1 tammik. 2019
OKM-julkaisutyyppiA4 Artikkeli konferenssijulkaisussa
TapahtumaSPIE Medical Imaging: Image-Guided Procedures, Robotic Interventions, and Modeling - San Diego, Yhdysvallat
Kesto: 17 helmik. 201919 helmik. 2019

Julkaisusarja

NimiProceedings of SPIE
Vuosikerta10951
ISSN (painettu)1605-7422

Conference

ConferenceSPIE Medical Imaging
Maa/AlueYhdysvallat
KaupunkiSan Diego
Ajanjakso17/02/201919/02/2019

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