Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

Elli Käpylä; Tomáš Sedlačík; Dogu Baran Aydogan; Jouko Viitanen; František Rypáček; Minna Kellomäki

doi:10.1016/j.msec.2014.07.027

Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

Elli Käpylä^*
, Tomáš Sedlačík
, Dogu Baran Aydogan
, Jouko Viitanen
, František Rypáček
, Minna Kellomäki

^*Tämän työn vastaava kirjoittaja

Ei julkaistu Aalto-yliopiston affiliaatiolla

Tampere University of Technology
BioMediTech Finland
Czech Academy of Sciences
VTT Technical Research Centre of Finland Ltd.

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

44 Sitaatiot (Scopus)

Abstrakti

The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

Alkuperäiskieli	Englanti
Sivut	280-289
Sivumäärä	10
Julkaisu	Materials Science and Engineering C: Materials for Biological Applications
Vuosikerta	43
DOI - pysyväislinkit	https://doi.org/10.1016/j.msec.2014.07.027
Tila	Julkaistu - 1 lokak. 2014
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

E.K. was financially supported by the Finnish Cultural Foundation and the Doctoral Program of Tampere University of Technology's President . E.K. and M.K. were also supported by the TEKES (the Finnish Funding Agency for Technology and Innovation) Human Spare Parts project. T.S. and F.R. were supported by Czech Science Foundation (Grant No.: P108/11/1857 ). The authors gratefully acknowledge M.Sc. (Eng.) Taru Karhula for SEM imaging.

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10.1016/j.msec.2014.07.027

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title = "Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization",

abstract = "The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.",

keywords = "Direct laser writing, Hydrogel, Microfabrication, Poly(ethylene glycol) diacrylate, Polyamino acid, Two-photon polymerization",

author = "Elli K{\"a}pyl{\"a} and Tom{\'a}{\v s} Sedla{\v c}{\'i}k and Aydogan, \{Dogu Baran\} and Jouko Viitanen and Franti{\v s}ek Ryp{\'a}{\v c}ek and Minna Kellom{\"a}ki",

year = "2014",

month = oct,

day = "1",

doi = "10.1016/j.msec.2014.07.027",

language = "English",

volume = "43",

pages = "280--289",

journal = "Materials Science and Engineering C: Materials for Biological Applications",

issn = "0928-4931",

publisher = "Elsevier",

}

Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization. / Käpylä, Elli; Sedlačík, Tomáš; Aydogan, Dogu Baran et al.
julkaisussa: Materials Science and Engineering C: Materials for Biological Applications, Vuosikerta 43, 01.10.2014, s. 280-289.

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

TY - JOUR

T1 - Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

AU - Käpylä, Elli

AU - Sedlačík, Tomáš

AU - Aydogan, Dogu Baran

AU - Viitanen, Jouko

AU - Rypáček, František

AU - Kellomäki, Minna

PY - 2014/10/1

Y1 - 2014/10/1

N2 - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

AB - The additive manufacturing technique of direct laser writing by two-photon polymerization (2PP-DLW) enables the fabrication of three-dimensional microstructures with superior accuracy and flexibility. When combined with biomimetic hydrogel materials, 2PP-DLW can be used to recreate the microarchitectures of the extracellular matrix. However, there are currently only a limited number of hydrogels applicable for 2PP-DLW. In order to widen the selection of synthetic biodegradable hydrogels, in this work we studied the 2PP-DLW of methacryloylated and acryloylated poly(α-amino acid)s (poly(AA)s). The performance of these materials was compared to widely used poly(ethylene glycol) diacrylates (PEGdas) in terms of polymerization and damage thresholds, voxel size, line width, post-polymerization swelling and deformation. We found that both methacryloylated and acryloylated poly(AA) hydrogels are suitable to 2PP-DLW with a wider processing window than PEGdas. The poly(AA) with the highest degree of acryloylation showed the greatest potential for 3D microfabrication.

KW - Direct laser writing

KW - Hydrogel

KW - Microfabrication

KW - Poly(ethylene glycol) diacrylate

KW - Polyamino acid

KW - Two-photon polymerization

UR - https://www.scopus.com/pages/publications/84904903147

U2 - 10.1016/j.msec.2014.07.027

DO - 10.1016/j.msec.2014.07.027

M3 - Article

C2 - 25175215

AN - SCOPUS:84904903147

SN - 0928-4931

VL - 43

SP - 280

EP - 289

JO - Materials Science and Engineering C: Materials for Biological Applications

JF - Materials Science and Engineering C: Materials for Biological Applications

ER -

Direct laser writing of synthetic poly(amino acid) hydrogels and poly(ethylene glycol) diacrylates by two-photon polymerization

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