Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

Rubina Ajdary; Guillermo Reyes Torres; Jani Kuula; Eija Raussi-Lehto; Tomi S. Mikkola; Esko Kankuri; Orlando Rojas Gaona

doi:10.1021/acspolymersau.1c00045

Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

Rubina Ajdary, Guillermo Reyes Torres, Jani Kuula, Eija Raussi-Lehto, Tomi S. Mikkola, Esko Kankuri, Orlando Rojas Gaona^*

^*Tämän työn vastaava kirjoittaja

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

37 Lataukset (Pure)

Abstrakti

Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.

Alkuperäiskieli	Englanti
Sivut	97–107
Sivumäärä	11
Julkaisu	ACS Polymers Au
Vuosikerta	2
Numero	2
Varhainen verkossa julkaisun päivämäärä	10 jouluk. 2021
DOI - pysyväislinkit	https://doi.org/10.1021/acspolymersau.1c00045
Tila	Julkaistu - 13 huhtik. 2022
OKM-julkaisutyyppi	A1 Julkaistu artikkeli, soviteltu

YK:n kestävän kehityksen tavoitteet

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10.1021/acspolymersau.1c00045Lisenssi: CC BY-NC-ND

CHEM_Ajdary_et_al_Direct_Ink_Writing_2022_ACS_Polymers_AuFinal published version, 11,5 MBLisenssi: CC BY-NC-ND

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Koko teksti

1 Päättynyt
1 Aktiivinen

BioELCell: Bioproducts Engineered from Lignocelluloses: from plants and upcycling to next generation materials
Rojas Gaona, O., Abidnejad, R., Ajdary, R., Bhattarai, M., Garcia Greca, L., Klockars, K., Dufau Mattos, B., Zhu, Y., Zhao, B., Majoinen, J., Tardy, B., Ressouche, E., Kämäräinen, T., Robertson, D., Reyes Torres, G. & Johansson, L.
30/07/2018 → 31/07/2023
Projekti: EU: ERC grants
Solving the Mesh
Nieminen, H.
01/02/2020 → 30/09/2022
Projekti: Business Finland: New business from research ideas (TUTLI)

OtaNano
Anna Rissanen (Manager)
Aalto-yliopisto
Laitteistot/tilat: Facility
OtaNano Nanomikroskopiakeskus
Jani Seitsonen (Manager)
OtaNano
Laitteistot/tilat: Facility

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@article{5c598c73660c40d4aa05b7432d183e23,

title = "Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices",

abstract = "Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.",

keywords = "Nanocellulose, Chitosan, Layer-by-layer meshes, Direct ink writing, Medical implants",

author = "Rubina Ajdary and {Reyes Torres}, Guillermo and Jani Kuula and Eija Raussi-Lehto and Mikkola, {Tomi S.} and Esko Kankuri and {Rojas Gaona}, Orlando",

note = "| openaire: EC/H2020/788489/EU//BioELCell ",

year = "2022",

month = apr,

day = "13",

doi = "10.1021/acspolymersau.1c00045",

language = "English",

volume = "2",

pages = "97–107",

journal = "ACS Polymers Au",

issn = "2694-2453",

publisher = "AMERICAN CHEMICAL SOCIETY",

number = "2",

}

TY - JOUR

T1 - Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

AU - Ajdary, Rubina

AU - Reyes Torres, Guillermo

AU - Kuula, Jani

AU - Raussi-Lehto, Eija

AU - Mikkola, Tomi S.

AU - Kankuri, Esko

AU - Rojas Gaona, Orlando

N1 - | openaire: EC/H2020/788489/EU//BioELCell

PY - 2022/4/13

Y1 - 2022/4/13

N2 - Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.

AB - Direct ink writing via single or multihead extrusion is used to synthesize layer-by-layer (LbL) meshes comprising renewable polysaccharides. The best mechanical performance (683 ± 63 MPa modulus and 2.5 ± 0.4 MPa tensile strength) is observed for 3D printed structures with full infill density, given the role of electrostatic complexation between the oppositely charged components (chitosan and cellulose nanofibrils). The LbL structures develop an unexpectedly high wet stability that undergoes gradual weight loss at neutral and slightly acidic pH. The excellent biocompatibility and noncytotoxicity toward human monocyte/macrophages and controllable shrinkage upon solvent exchange make the cellular meshes appropriate for use as biomedical implants.

KW - Nanocellulose

KW - Chitosan

KW - Layer-by-layer meshes

KW - Direct ink writing

KW - Medical implants

U2 - 10.1021/acspolymersau.1c00045

DO - 10.1021/acspolymersau.1c00045

M3 - Article

VL - 2

SP - 97

EP - 107

JO - ACS Polymers Au

JF - ACS Polymers Au

SN - 2694-2453

IS - 2

ER -

Direct Ink Writing of Biocompatible Nanocellulose and Chitosan Hydrogels for Implant Mesh Matrices

Abstrakti

YK:n kestävän kehityksen tavoitteet

Pääsy asiakirjaan

SFX-saatavuus

Sormenjälki

Projektit

BioELCell: Bioproducts Engineered from Lignocelluloses: from plants and upcycling to next generation materials

Solving the Mesh

Laitteet

OtaNano

OtaNano Nanomikroskopiakeskus

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