Abstrakti
Novel, substituted chromenopyrrolidininones have been synthesized from natural amino acid derivatives through an unprecedented sequence involving a Knoevenagel-Transesterification sequence and an allylative palladium-catalyzed cyclization reaction. The products are nature-inspired heterocycles derived from natural amino acids. The targets could be synthesized with varying degrees of stereoselectivity: racemization is a known issue with amino acids and provided a formidable challenge to our method development, as well. Altogether, six derivatives were synthesized with yields from moderate to good.
Alkuperäiskieli | Englanti |
---|---|
Sivut | 1512-1518 |
Sivumäärä | 7 |
Julkaisu | Synlett |
Vuosikerta | 34 |
Numero | 12 |
DOI - pysyväislinkit | |
Tila | Julkaistu - 3 tammik. 2023 |
OKM-julkaisutyyppi | A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä |
Sormenjälki
Sukella tutkimusaiheisiin 'Diastereoselective Synthesis of Substituted Chromenopyrrolidinones from Amino Acid-Derived Nitriles'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.Lehtileikkeet
-
Data on Chemicals and Chemistry Reported by Researchers at Aalto University (Diastereoselective Synthesis of Substituted Chromenopyrrolidinones From Amino Acid Derived Nitriles)
25/04/2023
1 kohde/ Medianäkyvyys
Lehdistö/media: Esiintyminen mediassa