Diastereoselective Synthesis of Substituted Chromenopyrrolidinones from Amino Acid-Derived Nitriles

Annakaisa Heikinheimo, Martin Nieger, Ari M.P. Koskinen*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

Abstrakti

Novel, substituted chromenopyrrolidininones have been synthesized from natural amino acid derivatives through an unprecedented sequence involving a Knoevenagel-Transesterification sequence and an allylative palladium-catalyzed cyclization reaction. The products are nature-inspired heterocycles derived from natural amino acids. The targets could be synthesized with varying degrees of stereoselectivity: racemization is a known issue with amino acids and provided a formidable challenge to our method development, as well. Altogether, six derivatives were synthesized with yields from moderate to good.

AlkuperäiskieliEnglanti
SivutA-G
JulkaisuSynlett
Vuosikerta36
DOI - pysyväislinkit
TilaJulkaistu - 3 tammik. 2023
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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