Development of human somatosensory cortical functions - what have we learned from magnetoencephalography: a review

Paivi Nevalainen, Leena Lauronen, Elina Pihko

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

52 Sitaatiot (Scopus)
82 Lataukset (Pure)

Abstrakti

The mysteries of early development of cortical processing in humans have started to unravel with the help of new non-invasive brain research tools like multichannel magnetoencephalography (MEG). In this review, we evaluate, within a wider neuroscientific and clinical context, the value of MEG in studying normal and disturbed functional development of the human somatosensory system. The combination of excellent temporal resolution and good localization accuracy provided by MEG has, in the case of somatosensory studies, enabled the differentiation of activation patterns from the newborn’s primary (SI) and secondary somatosensory (SII) areas. Furthermore, MEG has shown that the functioning of both SI and SII in newborns has particular immature features in comparison with adults. In extremely preterm infants, the neonatal MEG response from SII also seems to potentially predict developmental outcome: those lacking SII responses at term show worse motor performance at age 2 years than those with normal SII responses at term. In older children with unilateral early brain lesions, bilateral alterations in somatosensory cortical activation detected in MEG imply that the impact of a localized insult may have an unexpectedly wide effect on cortical somatosensory networks. The achievements over the last decade show that MEG provides a unique approach for studying the development of the somatosensory system and its disturbances in childhood. MEG well complements other neuroimaging methods in studies of cortical processes in the developing brain.
AlkuperäiskieliEnglanti
Artikkeli158
Sivut1-15
JulkaisuFRONTIERS IN HUMAN NEUROSCIENCE
Vuosikerta8
DOI - pysyväislinkit
TilaJulkaistu - 2014
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

Tutkimusalat

  • cerebral palsy
  • magnetoencephalography
  • newborn, brain development
  • preterm infant
  • somatosensory system

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