Designed inorganic porous nanovector with controlled release and MRI features for safe administration of doxorubicin

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

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Designed inorganic porous nanovector with controlled release and MRI features for safe administration of doxorubicin. / Näkki, Simo; Wang, Julie T.W.; Wu, Jianwei; Fan, Li; Rantanen, Jimi; Nissinen, Tuomo; Kettunen, Mikko I.; Backholm, Matilda; Ras, Robin H.A.; Al-Jamal, Khuloud T.; Lehto, Vesa Pekka; Xu, Wujun.

julkaisussa: International Journal of Pharmaceutics, Vuosikerta 554, 10.01.2019, s. 327-336.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Harvard

Näkki, S, Wang, JTW, Wu, J, Fan, L, Rantanen, J, Nissinen, T, Kettunen, MI, Backholm, M, Ras, RHA, Al-Jamal, KT, Lehto, VP & Xu, W 2019, 'Designed inorganic porous nanovector with controlled release and MRI features for safe administration of doxorubicin', International Journal of Pharmaceutics, Vuosikerta. 554, Sivut 327-336. https://doi.org/10.1016/j.ijpharm.2018.10.074

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Author

Näkki, Simo ; Wang, Julie T.W. ; Wu, Jianwei ; Fan, Li ; Rantanen, Jimi ; Nissinen, Tuomo ; Kettunen, Mikko I. ; Backholm, Matilda ; Ras, Robin H.A. ; Al-Jamal, Khuloud T. ; Lehto, Vesa Pekka ; Xu, Wujun. / Designed inorganic porous nanovector with controlled release and MRI features for safe administration of doxorubicin. Julkaisussa: International Journal of Pharmaceutics. 2019 ; Vuosikerta 554. Sivut 327-336.

Bibtex - Lataa

@article{a5b4db75af26462d8fd8386adb440a65,
title = "Designed inorganic porous nanovector with controlled release and MRI features for safe administration of doxorubicin",
abstract = "The inability of traditional chemotherapeutics to reach cancer tissue reduces the treatment efficacy and leads to adverse effects. A multifunctional nanovector was developed consisting of porous silicon, superparamagnetic iron oxide, calcium carbonate, doxorubicin and polyethylene glycol. The particles integrate magnetic properties with the capacity to retain drug molecules inside the pore matrix at neutral pH to facilitate drug delivery to tumor tissues. The MRI applicability and pH controlled drug release were examined in vitro together with in-depth material characterization. The in vivo biodistribution and compound safety were verified using A549 lung cancer bearing mice before proceeding to therapeutic experiments using CT26 cancer implanted mice. Loading doxorubicin into the porous nanoparticle negated the adverse side effects encountered after intravenous administration highlighting the particles’ excellent biocompatibility. Furthermore, the multifunctional nanovector induced 77{\%} tumor reduction after intratumoral injection. The anti-tumor effect was comparable with that of free doxorubicin but with significantly alleviated unwanted effects. These results demonstrate that the developed porous silicon-based nanoparticles represent promising multifunctional drug delivery vectors for cancer monitoring and therapy.",
keywords = "Biocompatibility, Cancer therapy, Nanoparticle, Porous silicon, Safety, Theranostics",
author = "Simo N{\"a}kki and Wang, {Julie T.W.} and Jianwei Wu and Li Fan and Jimi Rantanen and Tuomo Nissinen and Kettunen, {Mikko I.} and Matilda Backholm and Ras, {Robin H.A.} and Al-Jamal, {Khuloud T.} and Lehto, {Vesa Pekka} and Wujun Xu",
note = "Embargo 12 kk",
year = "2019",
month = "1",
day = "10",
doi = "10.1016/j.ijpharm.2018.10.074",
language = "English",
volume = "554",
pages = "327--336",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

}

RIS - Lataa

TY - JOUR

T1 - Designed inorganic porous nanovector with controlled release and MRI features for safe administration of doxorubicin

AU - Näkki, Simo

AU - Wang, Julie T.W.

AU - Wu, Jianwei

AU - Fan, Li

AU - Rantanen, Jimi

AU - Nissinen, Tuomo

AU - Kettunen, Mikko I.

AU - Backholm, Matilda

AU - Ras, Robin H.A.

AU - Al-Jamal, Khuloud T.

AU - Lehto, Vesa Pekka

AU - Xu, Wujun

N1 - Embargo 12 kk

PY - 2019/1/10

Y1 - 2019/1/10

N2 - The inability of traditional chemotherapeutics to reach cancer tissue reduces the treatment efficacy and leads to adverse effects. A multifunctional nanovector was developed consisting of porous silicon, superparamagnetic iron oxide, calcium carbonate, doxorubicin and polyethylene glycol. The particles integrate magnetic properties with the capacity to retain drug molecules inside the pore matrix at neutral pH to facilitate drug delivery to tumor tissues. The MRI applicability and pH controlled drug release were examined in vitro together with in-depth material characterization. The in vivo biodistribution and compound safety were verified using A549 lung cancer bearing mice before proceeding to therapeutic experiments using CT26 cancer implanted mice. Loading doxorubicin into the porous nanoparticle negated the adverse side effects encountered after intravenous administration highlighting the particles’ excellent biocompatibility. Furthermore, the multifunctional nanovector induced 77% tumor reduction after intratumoral injection. The anti-tumor effect was comparable with that of free doxorubicin but with significantly alleviated unwanted effects. These results demonstrate that the developed porous silicon-based nanoparticles represent promising multifunctional drug delivery vectors for cancer monitoring and therapy.

AB - The inability of traditional chemotherapeutics to reach cancer tissue reduces the treatment efficacy and leads to adverse effects. A multifunctional nanovector was developed consisting of porous silicon, superparamagnetic iron oxide, calcium carbonate, doxorubicin and polyethylene glycol. The particles integrate magnetic properties with the capacity to retain drug molecules inside the pore matrix at neutral pH to facilitate drug delivery to tumor tissues. The MRI applicability and pH controlled drug release were examined in vitro together with in-depth material characterization. The in vivo biodistribution and compound safety were verified using A549 lung cancer bearing mice before proceeding to therapeutic experiments using CT26 cancer implanted mice. Loading doxorubicin into the porous nanoparticle negated the adverse side effects encountered after intravenous administration highlighting the particles’ excellent biocompatibility. Furthermore, the multifunctional nanovector induced 77% tumor reduction after intratumoral injection. The anti-tumor effect was comparable with that of free doxorubicin but with significantly alleviated unwanted effects. These results demonstrate that the developed porous silicon-based nanoparticles represent promising multifunctional drug delivery vectors for cancer monitoring and therapy.

KW - Biocompatibility

KW - Cancer therapy

KW - Nanoparticle

KW - Porous silicon

KW - Safety

KW - Theranostics

UR - http://www.scopus.com/inward/record.url?scp=85056659679&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2018.10.074

DO - 10.1016/j.ijpharm.2018.10.074

M3 - Article

AN - SCOPUS:85056659679

VL - 554

SP - 327

EP - 336

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

ER -

ID: 30129729