Correlation between Ionic Liquid Cytotoxicity and Liposome–Ionic Liquid Interactions

Tutkimustuotos: Lehtiartikkeli

Standard

Correlation between Ionic Liquid Cytotoxicity and Liposome–Ionic Liquid Interactions. / Ruokonen, Suvi Katriina; Sanwald, Corinna; Robciuc, Alexandra; Hietala, Sami; Rantamäki, Antti H.; Witos, Joanna; King, Alistair W.T.; Lämmerhofer, Michael; Wiedmer, Susanne K.

julkaisussa: CHEMISTRY: A EUROPEAN JOURNAL, Vuosikerta 24, Nro 11, 21.02.2018, s. 2669-2680.

Tutkimustuotos: Lehtiartikkeli

Harvard

Ruokonen, SK, Sanwald, C, Robciuc, A, Hietala, S, Rantamäki, AH, Witos, J, King, AWT, Lämmerhofer, M & Wiedmer, SK 2018, 'Correlation between Ionic Liquid Cytotoxicity and Liposome–Ionic Liquid Interactions', CHEMISTRY: A EUROPEAN JOURNAL, Vuosikerta. 24, Nro 11, Sivut 2669-2680. https://doi.org/10.1002/chem.201704924

APA

Ruokonen, S. K., Sanwald, C., Robciuc, A., Hietala, S., Rantamäki, A. H., Witos, J., ... Wiedmer, S. K. (2018). Correlation between Ionic Liquid Cytotoxicity and Liposome–Ionic Liquid Interactions. CHEMISTRY: A EUROPEAN JOURNAL, 24(11), 2669-2680. https://doi.org/10.1002/chem.201704924

Vancouver

Author

Ruokonen, Suvi Katriina ; Sanwald, Corinna ; Robciuc, Alexandra ; Hietala, Sami ; Rantamäki, Antti H. ; Witos, Joanna ; King, Alistair W.T. ; Lämmerhofer, Michael ; Wiedmer, Susanne K. / Correlation between Ionic Liquid Cytotoxicity and Liposome–Ionic Liquid Interactions. Julkaisussa: CHEMISTRY: A EUROPEAN JOURNAL. 2018 ; Vuosikerta 24, Nro 11. Sivut 2669-2680.

Bibtex - Lataa

@article{d339bf12702b4cb3997dd787f0771851,
title = "Correlation between Ionic Liquid Cytotoxicity and Liposome–Ionic Liquid Interactions",
abstract = "This study aims at extending the understanding of the toxicity mechanism of ionic liquids (ILs) using various analytical methods and cytotoxicity assays. The cytotoxicity of eight ILs and one zwitterionic compound was determined using mammalian and bacterial cells. The time dependency of the IL toxicity was assessed using human corneal epithelial cells. Hemolysis was performed using human red blood cells and the results were compared with destabilization data of synthetic liposomes upon addition of ILs. The effect of the ILs on the size and zeta potential of liposomes revealed information on changes in the lipid bilayer. Differential scanning calorimetry was used to study the penetration of the ILs into the lipid bilayer. Pulsed field gradient nuclear magnetic resonance spectroscopy was used to determine whether the ILs occurred as unimers, micelles, or if they were bound to liposomes. The results show that the investigated ILs can be divided into three groups based on the cytotoxicity mechanism: cell wall disrupting ILs, ILs exerting toxicity through both cell wall penetration and metabolic alteration, and ILs affecting solely on cell metabolism.",
keywords = "analytical methods, cytotoxicity, ionic liquids, liposomes, toxicology",
author = "Ruokonen, {Suvi Katriina} and Corinna Sanwald and Alexandra Robciuc and Sami Hietala and Rantam{\"a}ki, {Antti H.} and Joanna Witos and King, {Alistair W.T.} and Michael L{\"a}mmerhofer and Wiedmer, {Susanne K.}",
year = "2018",
month = "2",
day = "21",
doi = "10.1002/chem.201704924",
language = "English",
volume = "24",
pages = "2669--2680",
journal = "CHEMISTRY: A EUROPEAN JOURNAL",
issn = "0947-6539",
number = "11",

}

RIS - Lataa

TY - JOUR

T1 - Correlation between Ionic Liquid Cytotoxicity and Liposome–Ionic Liquid Interactions

AU - Ruokonen, Suvi Katriina

AU - Sanwald, Corinna

AU - Robciuc, Alexandra

AU - Hietala, Sami

AU - Rantamäki, Antti H.

AU - Witos, Joanna

AU - King, Alistair W.T.

AU - Lämmerhofer, Michael

AU - Wiedmer, Susanne K.

PY - 2018/2/21

Y1 - 2018/2/21

N2 - This study aims at extending the understanding of the toxicity mechanism of ionic liquids (ILs) using various analytical methods and cytotoxicity assays. The cytotoxicity of eight ILs and one zwitterionic compound was determined using mammalian and bacterial cells. The time dependency of the IL toxicity was assessed using human corneal epithelial cells. Hemolysis was performed using human red blood cells and the results were compared with destabilization data of synthetic liposomes upon addition of ILs. The effect of the ILs on the size and zeta potential of liposomes revealed information on changes in the lipid bilayer. Differential scanning calorimetry was used to study the penetration of the ILs into the lipid bilayer. Pulsed field gradient nuclear magnetic resonance spectroscopy was used to determine whether the ILs occurred as unimers, micelles, or if they were bound to liposomes. The results show that the investigated ILs can be divided into three groups based on the cytotoxicity mechanism: cell wall disrupting ILs, ILs exerting toxicity through both cell wall penetration and metabolic alteration, and ILs affecting solely on cell metabolism.

AB - This study aims at extending the understanding of the toxicity mechanism of ionic liquids (ILs) using various analytical methods and cytotoxicity assays. The cytotoxicity of eight ILs and one zwitterionic compound was determined using mammalian and bacterial cells. The time dependency of the IL toxicity was assessed using human corneal epithelial cells. Hemolysis was performed using human red blood cells and the results were compared with destabilization data of synthetic liposomes upon addition of ILs. The effect of the ILs on the size and zeta potential of liposomes revealed information on changes in the lipid bilayer. Differential scanning calorimetry was used to study the penetration of the ILs into the lipid bilayer. Pulsed field gradient nuclear magnetic resonance spectroscopy was used to determine whether the ILs occurred as unimers, micelles, or if they were bound to liposomes. The results show that the investigated ILs can be divided into three groups based on the cytotoxicity mechanism: cell wall disrupting ILs, ILs exerting toxicity through both cell wall penetration and metabolic alteration, and ILs affecting solely on cell metabolism.

KW - analytical methods

KW - cytotoxicity

KW - ionic liquids

KW - liposomes

KW - toxicology

UR - http://www.scopus.com/inward/record.url?scp=85041013346&partnerID=8YFLogxK

U2 - 10.1002/chem.201704924

DO - 10.1002/chem.201704924

M3 - Article

VL - 24

SP - 2669

EP - 2680

JO - CHEMISTRY: A EUROPEAN JOURNAL

JF - CHEMISTRY: A EUROPEAN JOURNAL

SN - 0947-6539

IS - 11

ER -

ID: 21131889