Consciousness and cortical responsiveness: A within-state study during non-rapid eye movement sleep

Jaakko O. Nieminen, Olivia Gosseries, Marcello Massimini, Elyana Saad, Andrew D. Sheldon, Melanie Boly, Francesca Siclari, Bradley R. Postle, Giulio Tononi*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

23 Sitaatiot (Scopus)
70 Lataukset (Pure)

Abstrakti

When subjects become unconscious, there is a characteristic change in the way the cerebral cortex responds to perturbations, as can be assessed using transcranial magnetic stimulation and electroencephalography (TMS-EEG). For instance, compared to wakefulness, during non-rapid eye movement (NREM) sleep TMS elicits a larger positive-negative wave, fewer phase-locked oscillations, and an overall simpler response. However, many physiological variables also change when subjects go from wake to sleep, anesthesia, or coma. To avoid these confounding factors, we focused on NREM sleep only and measured TMS-evoked EEG responses before awakening the subjects and asking them if they had been conscious (dreaming) or not. As shown here, when subjects reported no conscious experience upon awakening, TMS evoked a larger negative deflection and a shorter phase-locked response compared to when they reported a dream. Moreover, the amplitude of the negative deflection-a hallmark of neuronal bistability according to intracranial studies-was inversely correlated with the length of the dream report (i.e., total word count). These findings suggest that variations in the level of consciousness within the same physiological state are associated with changes in the underlying bistability in cortical circuits.

AlkuperäiskieliEnglanti
Artikkeli30932
Sivut1-10
JulkaisuScientific Reports
Vuosikerta6
DOI - pysyväislinkit
TilaJulkaistu - 5 elokuuta 2016
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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  • Lehtileikkeet

    TMS differences between mind activity of people who dream and people who do not dream

    Jaakko Nieminen

    10/08/2016

    1 kohde/ Medianäkyvyys

    Lehdistö/media: Esiintyminen mediassa

    TMS differences between brain activity of people who dream and people who do not dream

    Jaakko Nieminen

    09/08/201610/08/2016

    4 kohdetta/ Medianäkyvyys

    Lehdistö/media: Esiintyminen mediassa

    Siteeraa tätä

    Nieminen, J. O., Gosseries, O., Massimini, M., Saad, E., Sheldon, A. D., Boly, M., ... Tononi, G. (2016). Consciousness and cortical responsiveness: A within-state study during non-rapid eye movement sleep. Scientific Reports, 6, 1-10. [30932]. https://doi.org/10.1038/srep30932