Conductive polyurethane/PEGylated graphene oxide composite for 3D-printed nerve guidance conduits

Afsoon Farzan, Sedigheh Borandeh, Jukka Seppälä*

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

10 Lataukset (Pure)

Abstrakti

Conductive polymeric nanocomposites have made significant contributions in nerve regeneration. To this aim, the best results are obtained by using nerve guidance conduits (NGCs) with conductive, bio-compatible, bio-degradable tubes as well as special topographical features. In this study, biodegradable, conductive, solvent-free polyurethane/PEGylated graphene oxide (PU/PEG-GO) composites were synthesized and successfully 3D printed into flexible nerve conduits with different precise geometries, such as hollow, porous, and grooved tubes, using stereolithography. The composite containing 5% PEG-GO showed the highest tensile stress (3.51 ± 0.54 MPa), tensile strain at break (∼170%), and conductivity (1.1 × 10−3 S/cm) with the lowest contact angle of 72° attributing to the strong interfacial interactions between PEG-GO nanosheets and the PU matrix. Moreover, the PU/PEG-GO 5% exhibited higher compression strength compared with pure PU and showed appropriate enzymatic degradation after 6 weeks, which is expected to last sufficiently for an efficient nerve regeneration. Altogether the 3D-printed, conductive, biodegradable, and flexible PU/PEG-GO 5% conduit with precise geometry has potential as NGCs for peripheral nerve regeneration.

AlkuperäiskieliEnglanti
Artikkeli111068
Sivumäärä11
JulkaisuEuropean Polymer Journal
Vuosikerta167
Varhainen verkossa julkaisun päivämäärä16 helmik. 2022
DOI - pysyväislinkit
TilaJulkaistu - 15 maalisk. 2022
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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