TY - JOUR
T1 - Comprehensive characterisation of the compressive behaviour of hydrogels using a new modelling procedure and redefining compression testing
AU - Nafar Dastgerdi, Jairan
AU - Koivisto, Janne T.
AU - Orell, Olli
AU - Rava, Pantea
AU - Jokinen, Jarno
AU - Kanerva, Mikko
AU - Kellomäki, Minna
N1 - Funding Information:
J.T. Koivisto and M. Kellomäki would like to thank the Human Spare Parts program of Business Finland and the Center of Excellence – Body on Chip (312409, 326587, 336663) of the Academy of Finland for the funding of this research. J.T. Koivisto would also like to acknowledge the support given by the Finnish Cultural Foundation the Pirkanmaa Regional Fund personal grant number 50151501 . J. Nafar Dastgerdi, O. Orell and M. Kanerva would like to thank the LuxTurrim5G project grant by Business Finland and the related subtask (10098/31/2016) about compression testing of polymers and polymer composites carried out by Tampere University of Technology. The authors wish to thank Peter Heath for help with language checking and proof-reading the manuscript. CSC–IT Center for Science (Finland) is acknowledged for computational resources.
Funding Information:
J.T. Koivisto and M. Kellom?ki would like to thank the Human Spare Parts program of Business Finland and the Center of Excellence ? Body on Chip (312409, 326587, 336663) of the Academy of Finlandfor the funding of this research. J.T. Koivisto would also like to acknowledge the support given by the Finnish Cultural Foundation the Pirkanmaa Regional Fund personal grant number 50151501. J. Nafar Dastgerdi, O. Orell and M. Kanerva would like to thank the LuxTurrim5G project grant by Business Finlandand the related subtask (10098/31/2016) about compression testing of polymers and polymer composites carried out by Tampere University of Technology. The authors wish to thank Peter Heath for help with language checking and proof-reading the manuscript. CSC?IT Center for Science (Finland) is acknowledged for computational resources.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/9
Y1 - 2021/9
N2 - The aim of tissue engineering is the regeneration of damaged tissue or the production of representative tissue organoids in vitro. To achieve this, one approach is to use hydrogels, water-swollen hydrophilic and crosslinked polymer networks, that can accommodate encapsulation of living cells and help the regeneration process. Even though mechanically biomimicking target tissue is important for a favorable cell response, the mechanical characterisation of tissues or hydrogels is not yet a fully defined process with various possible models and methods existing. In this paper, for the first time, a specific procedure and model has been suggested for the discussion of the nonlinear stress-strain relationship in large deformations of hydrogels. Moreover, this approach has comprehensively characterised the compressive material performance of hydrogels in a theoretical framework. To present the performance and utility of the introduced procedure, it is used with two different compositions of bioamine crosslinked gellan gum hydrogel. In addition, a three-dimensional digital image correlation technique has been utilized together with compression testing to measure the actual force and deformation in unconfined compression. The material model parameters were obtained to represent nonlinear stress-strain behaviour and the viscoelastic response (relaxation) of gellan gum hydrogel in compression.
AB - The aim of tissue engineering is the regeneration of damaged tissue or the production of representative tissue organoids in vitro. To achieve this, one approach is to use hydrogels, water-swollen hydrophilic and crosslinked polymer networks, that can accommodate encapsulation of living cells and help the regeneration process. Even though mechanically biomimicking target tissue is important for a favorable cell response, the mechanical characterisation of tissues or hydrogels is not yet a fully defined process with various possible models and methods existing. In this paper, for the first time, a specific procedure and model has been suggested for the discussion of the nonlinear stress-strain relationship in large deformations of hydrogels. Moreover, this approach has comprehensively characterised the compressive material performance of hydrogels in a theoretical framework. To present the performance and utility of the introduced procedure, it is used with two different compositions of bioamine crosslinked gellan gum hydrogel. In addition, a three-dimensional digital image correlation technique has been utilized together with compression testing to measure the actual force and deformation in unconfined compression. The material model parameters were obtained to represent nonlinear stress-strain behaviour and the viscoelastic response (relaxation) of gellan gum hydrogel in compression.
KW - Compression testing
KW - Gellan gum
KW - Hydrogel
KW - Mechanical properties
KW - Viscoelastic deformation
UR - http://www.scopus.com/inward/record.url?scp=85107997063&partnerID=8YFLogxK
U2 - 10.1016/j.mtcomm.2021.102518
DO - 10.1016/j.mtcomm.2021.102518
M3 - Article
AN - SCOPUS:85107997063
VL - 28
JO - Materials Today Communications
JF - Materials Today Communications
SN - 2352-4928
M1 - 102518
ER -