Clickable, biocompatible, and fluorescent hybrid nanoparticles for intracellular delivery and optical imaging

Markus Müllner, Anja Schallon, Andreas Walther, Ruth Freitag, Axel H.E. Müller

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

41 Sitaatiot (Scopus)

Abstrakti

We report a general and facile approach for the fabrication of a new class of near monodisperse hybrid nanoparticles via RAFT polymerization and self-assembly in water. Furthermore, we combine a fluorescent inorganic silica core with a biocompatible polymer shell and a terminal unit susceptible to facile conjugations via click chemistry. A tailoring of the weight fractions of both components allows a tuning of the size of the formed aggregates. Fluorescent properties and the crosslinking into an organic-inorganic hybrid network are realized by copolymerizing a dye-functionalized monomer 1-pyrenebutyl acrylate and a trimethoxysilane-carrying one, (3-acryloxypropyl)- trimethoxysilane. The potential of these stabilized and fluorescent nanoparticles as biocompatible carriers for intracellular delivery is demonstrated via in vitro experiments on lung cancer cells.

AlkuperäiskieliEnglanti
Sivut390-396
Sivumäärä7
JulkaisuBiomacromolecules
Vuosikerta11
Numero2
DOI - pysyväislinkit
TilaJulkaistu - 8 helmikuuta 2010
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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