Chemical analysis using 3D printed glass microfluidics

Eran Gal-Or*, Yaniv Gershoni, Gianmario Scotti, Sofia M.E. Nilsson, Jukka Saarinen, Ville Jokinen, Clare J. Strachan, Gustav Boije Af Gennäs, Jari Yli-Kauhaluoma, Tapio Kotiaho

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

18 Sitaatiot (Scopus)
162 Lataukset (Pure)

Abstrakti

Additive manufacturing (3D printing) is a disruptive technology that is changing production systems globally. In addition, microfluidic devices are increasingly being used for chemical analysis and continuous production of chemicals. Printing of materials such as polymers and metals is already a reality, but additive manufacturing of glass for microfluidic systems has received minor attention. We characterize microfluidic devices (channel cross-section dimensions down to a scale of 100 μm) that have been produced by additive manufacturing of molten soda-lime glass in tens of minutes and report their mass spectrometric and Raman spectroscopic analysis examples. The functionality of a microfluidic glass microreactor is shown with online mass spectrometric analysis of linezolid synthesis. Additionally, the performance of a direct infusion device is demonstrated by mass spectrometric analysis of drugs. Finally, the excellent optical quality of the glass structures is demonstrated with in-line Raman spectroscopic measurements. Our results promise a bright future for additively manufactured glass microdevices in diverse fields of science.

AlkuperäiskieliEnglanti
Sivut1802-1810
Sivumäärä9
JulkaisuANALYTICAL METHODS
Vuosikerta11
Numero13
DOI - pysyväislinkit
TilaJulkaistu - 7 huhtikuuta 2019
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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