Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

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Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography. / Markl, Daniel ; Wang, Parry; Ridgway, Cathy; Karttunen, Anssi Pekka; Chakraborty, Mousumi; Bawuah, Prince; Pääkkönen, Pertti; Gane, Patrick; Ketolainen, Jarkko; Peiponen, Kai-Erik; Zeitler, J. Axel.

julkaisussa: Journal of Pharmaceutical Sciences, Vuosikerta 106, Nro 6, 05.2017, s. 1586–1595.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Harvard

Markl, D, Wang, P, Ridgway, C, Karttunen, AP, Chakraborty, M, Bawuah, P, Pääkkönen, P, Gane, P, Ketolainen, J, Peiponen, K-E & Zeitler, JA 2017, 'Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography', Journal of Pharmaceutical Sciences, Vuosikerta. 106, Nro 6, Sivut 1586–1595. https://doi.org/10.1016/j.xphs.2017.02.028

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Author

Markl, Daniel ; Wang, Parry ; Ridgway, Cathy ; Karttunen, Anssi Pekka ; Chakraborty, Mousumi ; Bawuah, Prince ; Pääkkönen, Pertti ; Gane, Patrick ; Ketolainen, Jarkko ; Peiponen, Kai-Erik ; Zeitler, J. Axel. / Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography. Julkaisussa: Journal of Pharmaceutical Sciences. 2017 ; Vuosikerta 106, Nro 6. Sivut 1586–1595.

Bibtex - Lataa

@article{0bdb0ac41a30434e97e66e3987f40150,
title = "Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography",
abstract = "Novel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and, thus, providing a rapid liquid uptake and disintegration to accelerate subsequent drug dissolution. One example of such a novel excipient is functionalized calcium carbonate, which enables the manufacture of compacts with a bimodal pore size distribution consisting of larger interparticle and fine intraparticle pores. Five sets of functionalized calcium carbonate tablets with a target porosity of 45{\%}-65{\%} were prepared in 5{\%} steps and characterized using terahertz time-domain spectroscopy and X-ray computed microtomography. Terahertz time-domain spectroscopy was used to derive the porosity using effective medium approximations, that is, the traditional and an anisotropic Bruggeman model. The anisotropic Bruggeman model yields the better correlation with the nominal porosity (R 2 = 0.995) and it provided additional information about the shape and orientation of the pores within the powder compact. The spheroidal (ellipsoids of revolution) shaped pores have a preferred orientation perpendicular to the compaction direction causing an anisotropic behavior of the dielectric porous medium. The results from X-ray computed microtomography confirmed the nonspherical shape and the orientation of the pores, and it further revealed that the anisotropic behavior is mainly caused by the interparticle pores. The information from both techniques provides a detailed insight into the pore structure of pharmaceutical tablets. This is of great interest to study the impact of tablet microstructure on the disintegration and dissolution performance.",
keywords = "Imaging methods, Mathematical models, Mechanical properties, Physical characterization, Refractive index, Solid dosage form, Spectroscopy",
author = "Daniel Markl and Parry Wang and Cathy Ridgway and Karttunen, {Anssi Pekka} and Mousumi Chakraborty and Prince Bawuah and Pertti P{\"a}{\"a}kk{\"o}nen and Patrick Gane and Jarkko Ketolainen and Kai-Erik Peiponen and Zeitler, {J. Axel}",
year = "2017",
month = "5",
doi = "10.1016/j.xphs.2017.02.028",
language = "English",
volume = "106",
pages = "1586–1595",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

RIS - Lataa

TY - JOUR

T1 - Characterization of the Pore Structure of Functionalized Calcium Carbonate Tablets by Terahertz Time-Domain Spectroscopy and X-Ray Computed Microtomography

AU - Markl, Daniel

AU - Wang, Parry

AU - Ridgway, Cathy

AU - Karttunen, Anssi Pekka

AU - Chakraborty, Mousumi

AU - Bawuah, Prince

AU - Pääkkönen, Pertti

AU - Gane, Patrick

AU - Ketolainen, Jarkko

AU - Peiponen, Kai-Erik

AU - Zeitler, J. Axel

PY - 2017/5

Y1 - 2017/5

N2 - Novel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and, thus, providing a rapid liquid uptake and disintegration to accelerate subsequent drug dissolution. One example of such a novel excipient is functionalized calcium carbonate, which enables the manufacture of compacts with a bimodal pore size distribution consisting of larger interparticle and fine intraparticle pores. Five sets of functionalized calcium carbonate tablets with a target porosity of 45%-65% were prepared in 5% steps and characterized using terahertz time-domain spectroscopy and X-ray computed microtomography. Terahertz time-domain spectroscopy was used to derive the porosity using effective medium approximations, that is, the traditional and an anisotropic Bruggeman model. The anisotropic Bruggeman model yields the better correlation with the nominal porosity (R 2 = 0.995) and it provided additional information about the shape and orientation of the pores within the powder compact. The spheroidal (ellipsoids of revolution) shaped pores have a preferred orientation perpendicular to the compaction direction causing an anisotropic behavior of the dielectric porous medium. The results from X-ray computed microtomography confirmed the nonspherical shape and the orientation of the pores, and it further revealed that the anisotropic behavior is mainly caused by the interparticle pores. The information from both techniques provides a detailed insight into the pore structure of pharmaceutical tablets. This is of great interest to study the impact of tablet microstructure on the disintegration and dissolution performance.

AB - Novel excipients are entering the market to enhance the bioavailability of drug particles by having a high porosity and, thus, providing a rapid liquid uptake and disintegration to accelerate subsequent drug dissolution. One example of such a novel excipient is functionalized calcium carbonate, which enables the manufacture of compacts with a bimodal pore size distribution consisting of larger interparticle and fine intraparticle pores. Five sets of functionalized calcium carbonate tablets with a target porosity of 45%-65% were prepared in 5% steps and characterized using terahertz time-domain spectroscopy and X-ray computed microtomography. Terahertz time-domain spectroscopy was used to derive the porosity using effective medium approximations, that is, the traditional and an anisotropic Bruggeman model. The anisotropic Bruggeman model yields the better correlation with the nominal porosity (R 2 = 0.995) and it provided additional information about the shape and orientation of the pores within the powder compact. The spheroidal (ellipsoids of revolution) shaped pores have a preferred orientation perpendicular to the compaction direction causing an anisotropic behavior of the dielectric porous medium. The results from X-ray computed microtomography confirmed the nonspherical shape and the orientation of the pores, and it further revealed that the anisotropic behavior is mainly caused by the interparticle pores. The information from both techniques provides a detailed insight into the pore structure of pharmaceutical tablets. This is of great interest to study the impact of tablet microstructure on the disintegration and dissolution performance.

KW - Imaging methods

KW - Mathematical models

KW - Mechanical properties

KW - Physical characterization

KW - Refractive index

KW - Solid dosage form

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=85017391273&partnerID=8YFLogxK

U2 - 10.1016/j.xphs.2017.02.028

DO - 10.1016/j.xphs.2017.02.028

M3 - Article

VL - 106

SP - 1586

EP - 1595

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 6

ER -

ID: 13017736