Characterisation of pore structures of pharmaceutical tablets: A review

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Standard

Characterisation of pore structures of pharmaceutical tablets : A review. / Markl, Daniel; Strobel, Alexa; Schlossnikl, Rüdiger; Bøtker, Johan; Bawuah, Prince; Ridgway, Cathy; Rantanen, Jukka; Rades, Thomas; Gane, Patrick; Peiponen, Kai Erik; Zeitler, J. Axel.

julkaisussa: International Journal of Pharmaceutics, Vuosikerta 538, Nro 1-2, 01.03.2018, s. 188-214.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Harvard

Markl, D, Strobel, A, Schlossnikl, R, Bøtker, J, Bawuah, P, Ridgway, C, Rantanen, J, Rades, T, Gane, P, Peiponen, KE & Zeitler, JA 2018, 'Characterisation of pore structures of pharmaceutical tablets: A review', International Journal of Pharmaceutics, Vuosikerta. 538, Nro 1-2, Sivut 188-214. https://doi.org/10.1016/j.ijpharm.2018.01.017

APA

Markl, D., Strobel, A., Schlossnikl, R., Bøtker, J., Bawuah, P., Ridgway, C., ... Zeitler, J. A. (2018). Characterisation of pore structures of pharmaceutical tablets: A review. International Journal of Pharmaceutics, 538(1-2), 188-214. https://doi.org/10.1016/j.ijpharm.2018.01.017

Vancouver

Markl D, Strobel A, Schlossnikl R, Bøtker J, Bawuah P, Ridgway C et al. Characterisation of pore structures of pharmaceutical tablets: A review. International Journal of Pharmaceutics. 2018 maalis 1;538(1-2):188-214. https://doi.org/10.1016/j.ijpharm.2018.01.017

Author

Markl, Daniel ; Strobel, Alexa ; Schlossnikl, Rüdiger ; Bøtker, Johan ; Bawuah, Prince ; Ridgway, Cathy ; Rantanen, Jukka ; Rades, Thomas ; Gane, Patrick ; Peiponen, Kai Erik ; Zeitler, J. Axel. / Characterisation of pore structures of pharmaceutical tablets : A review. Julkaisussa: International Journal of Pharmaceutics. 2018 ; Vuosikerta 538, Nro 1-2. Sivut 188-214.

Bibtex - Lataa

@article{3d46821f93c742ab84afed264567d5e8,
title = "Characterisation of pore structures of pharmaceutical tablets: A review",
abstract = "Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process. In future, additive manufacturing is a potential game changer to design the inner structures and realise a tailor-made pore structure. In pharmaceutical development the pore structure is most commonly only described by the total porosity of the tablet matrix. Yet it is of great importance to consider other parameters to fully resolve the interplay between microstructure and dosage form performance. Specifically, tortuosity, connectivity, as well as pore shape, size and orientation all impact the flow paths and play an important role in describing the fluid flow in a pharmaceutical tablet. This review presents the key properties of the pore structures in solid dosage forms and it discusses how to measure these properties. In particular, the principles, advantages and limitations of helium pycnometry, mercury porosimetry, terahertz time-domain spectroscopy, nuclear magnetic resonance and X-ray computed microtomography are discussed.",
keywords = "Helium pycnometry, Mercury porosimetry, Nuclear magnetic resonance, Pore structure, Solid dosage form, Terahertz technology, X-ray computed microtomography",
author = "Daniel Markl and Alexa Strobel and R{\"u}diger Schlossnikl and Johan B{\o}tker and Prince Bawuah and Cathy Ridgway and Jukka Rantanen and Thomas Rades and Patrick Gane and Peiponen, {Kai Erik} and Zeitler, {J. Axel}",
year = "2018",
month = "3",
day = "1",
doi = "10.1016/j.ijpharm.2018.01.017",
language = "English",
volume = "538",
pages = "188--214",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1-2",

}

RIS - Lataa

TY - JOUR

T1 - Characterisation of pore structures of pharmaceutical tablets

T2 - A review

AU - Markl, Daniel

AU - Strobel, Alexa

AU - Schlossnikl, Rüdiger

AU - Bøtker, Johan

AU - Bawuah, Prince

AU - Ridgway, Cathy

AU - Rantanen, Jukka

AU - Rades, Thomas

AU - Gane, Patrick

AU - Peiponen, Kai Erik

AU - Zeitler, J. Axel

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process. In future, additive manufacturing is a potential game changer to design the inner structures and realise a tailor-made pore structure. In pharmaceutical development the pore structure is most commonly only described by the total porosity of the tablet matrix. Yet it is of great importance to consider other parameters to fully resolve the interplay between microstructure and dosage form performance. Specifically, tortuosity, connectivity, as well as pore shape, size and orientation all impact the flow paths and play an important role in describing the fluid flow in a pharmaceutical tablet. This review presents the key properties of the pore structures in solid dosage forms and it discusses how to measure these properties. In particular, the principles, advantages and limitations of helium pycnometry, mercury porosimetry, terahertz time-domain spectroscopy, nuclear magnetic resonance and X-ray computed microtomography are discussed.

AB - Traditionally, the development of a new solid dosage form is formulation-driven and less focus is put on the design of a specific microstructure for the drug delivery system. However, the compaction process particularly impacts the microstructure, or more precisely, the pore architecture in a pharmaceutical tablet. Besides the formulation, the pore structure is a major contributor to the overall performance of oral solid dosage forms as it directly affects the liquid uptake rate, which is the very first step of the dissolution process. In future, additive manufacturing is a potential game changer to design the inner structures and realise a tailor-made pore structure. In pharmaceutical development the pore structure is most commonly only described by the total porosity of the tablet matrix. Yet it is of great importance to consider other parameters to fully resolve the interplay between microstructure and dosage form performance. Specifically, tortuosity, connectivity, as well as pore shape, size and orientation all impact the flow paths and play an important role in describing the fluid flow in a pharmaceutical tablet. This review presents the key properties of the pore structures in solid dosage forms and it discusses how to measure these properties. In particular, the principles, advantages and limitations of helium pycnometry, mercury porosimetry, terahertz time-domain spectroscopy, nuclear magnetic resonance and X-ray computed microtomography are discussed.

KW - Helium pycnometry

KW - Mercury porosimetry

KW - Nuclear magnetic resonance

KW - Pore structure

KW - Solid dosage form

KW - Terahertz technology

KW - X-ray computed microtomography

UR - http://www.scopus.com/inward/record.url?scp=85041123576&partnerID=8YFLogxK

U2 - 10.1016/j.ijpharm.2018.01.017

DO - 10.1016/j.ijpharm.2018.01.017

M3 - Review Article

VL - 538

SP - 188

EP - 214

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1-2

ER -

ID: 17418344