TY - JOUR
T1 - Cellular landscaping of cisplatin resistance in cervical cancer
AU - Bhattacharjee, Rahul
AU - Dey, Tanima
AU - Kumar, Lamha
AU - Kar, Sulagna
AU - Sarkar, Ritayan
AU - Ghorai, Mimosa
AU - Malik, Sumira
AU - Jha, Niraj Kumar
AU - Vellingiri, Balachandar
AU - Kesari, Kavindra Kumar
AU - Pérez de la Lastra, José M.
AU - Dey, Abhijit
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/9
Y1 - 2022/9
N2 - Cervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide. Cisplatin is one of the widely used drugs for the treatment of CC is rendered ineffective owing to drug resistance. This review highlights the cause of resistance and the mechanism of cisplatin resistance cells in CC to develop therapeutic ventures and strategies that could be utilized to overcome the aforementioned issue. These strategies would include the application of nanocarries, miRNA, CRIPSR/Cas system, and chemotherapeutics in synergy with cisplatin to not only overcome the issues of drug resistance but also enhance its anti-cancer efficiency. Moreover, we have also discussed the signaling network of cisplatin resistance cells in CC that would provide insights to develop therapeutic target sites and inhibitors. Furthermore, we have discussed the role of CC metabolism on cisplatin resistance cells and the physical and biological factors affecting the tumor microenvironments.
AB - Cervical cancer (CC) caused by human papillomavirus (HPV) is one of the largest causes of malignancies in women worldwide. Cisplatin is one of the widely used drugs for the treatment of CC is rendered ineffective owing to drug resistance. This review highlights the cause of resistance and the mechanism of cisplatin resistance cells in CC to develop therapeutic ventures and strategies that could be utilized to overcome the aforementioned issue. These strategies would include the application of nanocarries, miRNA, CRIPSR/Cas system, and chemotherapeutics in synergy with cisplatin to not only overcome the issues of drug resistance but also enhance its anti-cancer efficiency. Moreover, we have also discussed the signaling network of cisplatin resistance cells in CC that would provide insights to develop therapeutic target sites and inhibitors. Furthermore, we have discussed the role of CC metabolism on cisplatin resistance cells and the physical and biological factors affecting the tumor microenvironments.
KW - Anti-cancer activity
KW - Cell signaling
KW - Cervical cancer
KW - Chemotherapeutics
KW - Cisplatin resistance
KW - Drug resistance
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85134709790&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2022.113345
DO - 10.1016/j.biopha.2022.113345
M3 - Review Article
C2 - 35810692
AN - SCOPUS:85134709790
SN - 0753-3322
VL - 153
SP - 1
EP - 18
JO - Biomedicine and Pharmacotherapy
JF - Biomedicine and Pharmacotherapy
M1 - 113345
ER -
