Biodegradable lactone copolymers. II. Hydrolytic study of ε-caprolactone and lactide copolymers

M. Malin, M. Hiljanen-Vainio, T. Karjalainen, J. Seppälä*

*Tämän työn vastaava kirjoittaja

    Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

    110 Sitaatiot (Scopus)

    Abstrakti

    Copolymers of ε-CL/L-LA and ε-CL/DL-LA were allowed to age in a buffer solution of pH 7 at 23 and 37°C. The effects of time and temperature on the rate of hydrolysis were examined by various techniques including weighing (water absorption and weight loss), SEC (molecular weight and polydispersity), and DSC (thermal properties). For comparison, the hydrolytic behavior of PLLA, PDLLA, and commercial PCL homopolymers was investigated by the same methods. SEC measurements showed that molecular weights of the copolymers and PLA homopolymers started to decrease during the first week of hydrolysis, but significant mass losses occurred only much later. As expected, there was no change in either molecular weight or mass of PCL during the hydrolysis study. The kinetic results for copolymers and homopolymers were calculated to study the degradation mechanism. During hydrolysis, the crystallinity of the initially semicrystalline copolymers increased and some crystallinity appeared in the initially amorphous L-LA-containing copolymers.

    AlkuperäiskieliEnglanti
    Sivut1289-1298
    Sivumäärä10
    JulkaisuJournal of Applied Polymer Science
    Vuosikerta59
    Numero8
    DOI - pysyväislinkit
    TilaJulkaistu - 22 helmik. 1996
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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