Abstrakti
A series of alkylated 2,3-dihydroxybiphenyls has been prepared on the gram scale by using an effective Directed ortho Metalation–Suzuki–Miyaura cross-coupling strategy. These compounds have been used to investigate the substrate specificity of the meta-cleavage dioxygenase BphC, a key enzyme in the microbial catabolism of biphenyl. Isolation and characterization of the meta-cleavage products will allow further study of related processes, including the catabolism of lignin-derived biphenyls.
Alkuperäiskieli | Englanti |
---|---|
Sivut | 1771-1778 |
Julkaisu | ChemBioChem |
Vuosikerta | 19 |
Numero | 16 |
DOI - pysyväislinkit | |
Tila | Julkaistu - 16 elok. 2018 |
OKM-julkaisutyyppi | A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä |