Bacmeta: Simulator for genomic evolution in bacterial metapopulations

Tutkimustuotos: Lehtiartikkeli

Tutkijat

Organisaatiot

  • University of Helsinki
  • University of Oslo

Kuvaus

The advent of genomic data from densely sampled bacterial populations has created a need for flexible simulators by which models and hypotheses can be efficiently investigated in the light of empirical observations. Bacmeta provides fast stochastic simulation of neutral evolution within a large collection of interconnected bacterial populations with completely adjustable connectivity network. Stochastic events of mutations, recombinations, insertions/deletions, migrations and micro-epidemics can be simulated in discrete non-overlapping generations with a Wright?Fisher model that operates on explicit sequence data of any desired genome length. Each model component, including locus, bacterial strain, population and ultimately the whole metapopulation, is efficiently simulated using C++objects and detailed metadata from each level can be acquired. The software can be executed in a cluster environment using simple textual input files, enabling, e.g. large-scale simulations and likelihood-free inference.

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut2308-2310
Sivumäärä3
JulkaisuBioinformatics
Vuosikerta34
Numero13
TilaJulkaistu - 1 heinäkuuta 2018
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 27134379