Three types of highly-customizable open source probe positioning systems are evaluated: (a) mostly 3-D printed, (b) partially printed using OpenBeam kinematic constraints, and (c) a 3-level stack of low-cost commercial single axis micropositioners and some printed parts. All systems use digital distributed manufacturing to enable bespoke features, which can be fabricated with RepRap-class 3-D printer and easily accessible components. They are all flexible in material choice for custom components. The micropositioners can be set up for left-right use and flat or recessed configurations using either mechanical or magnetic mounting. All systems use a manual probe holder that can be customized and enable a quick swap probe system. System (a) is purchased for $100 or fabricated for 200 microns, (b) 40 microns and (c) 10 microns. A tradeoff is observed for 3-D printed percent between cost and accuracy. All systems provided substantial cost savings over proprietary products with similar functionality.