Antioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation

Tainise Vergara Lourencon*, Gabriel G. de Lima, Carolina S. P. Ribeiro, Fabrício A. Hansel, Giselle M. Maciel, Krisle da Silva, Sheila M. B. Winnischofer, Graciela I. B. de Muniz, Washington L E Magalhães

*Tämän työn vastaava kirjoittaja

Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

32 Sitaatiot (Scopus)
48 Lataukset (Pure)

Abstrakti

Kraft lignin, so far useful for energy generation, has been gathering considerable attention as an alternative material to replace fossil-based resources mainly due to its high phenolic content. However, the wide molecular weight distribution and chemical composition heterogeneity led to the development of fractionation methods. Herein, to narrow such characteristics we used eucalypt kraft lignin fractionated at pH's 9, 7, 5 and 3 by sequential acid precipitation. These lignin fractions were first characterised by simultaneous pyrolysis and trimethylsilylation (SPyT) with N-Methyl-N-(trimethylsilyl) trifluoroacetamide with posterior tests of antioxidant, antibacterial, and antitumour activities. We observed higher ratio of syringyl/guaiacyl groups and increase in antioxidant activity in those fractions with lower molecular weight (precipitated at lower pH's). Fractions precipitated at pH's 9 and 7 have shown an outstanding antibacterial activity against five bacteria. Moreover, fractions 7 and 5 presented at cytotoxicity tests higher ability to inhibit the growth of U87MG and T98G glioma cells, while only a slight inhibition of adult human fibroblasts (non-tumour cells) was detected.

AlkuperäiskieliEnglanti
Sivut1535-1542
Sivumäärä8
JulkaisuInternational Journal of Biological Macromolecules
Vuosikerta166
Varhainen verkossa julkaisun päivämäärä10 marrask. 2020
DOI - pysyväislinkit
TilaJulkaistu - 1 tammik. 2021
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

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