An improved method for synthesis of non-symmetric triarylpyridines

Arvind Negi; Styliana I. Mirallai; Saidulu Konda; Paul V. Murphy

doi:10.1016/j.tet.2022.132930

An improved method for synthesis of non-symmetric triarylpyridines

Arvind Negi, Styliana I. Mirallai, Saidulu Konda, Paul V. Murphy

Ei julkaistu Aalto-yliopiston affiliaatiolla

National University of Ireland, Galway

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

Abstrakti

The optimization of a multicomponent reaction, to prepare triarylpyridines (triphenylpyridine), and which includes 17 examples where each aryl substituent is distinct (non-symmetric pyridine) is reported. The non-symmetric triarylpyridine aqrar forming reaction involves the sequential addition of two different acetophenones to a benzylamine in DMF in the presence of copper (I) iodide (20 mol %), methanolic ammonia (2 equiv.), and oxygen. The optimized method was used to give twenty five different triarylpyridines in 43–91% yield, including products with a thiophene substituent and bipyridines.

Alkuperäiskieli	Englanti
Artikkeli	132930
Sivumäärä	13
Julkaisu	Tetrahedron
Vuosikerta	121
Varhainen verkossa julkaisun päivämäärä	17 elok. 2022
DOI - pysyväislinkit	https://doi.org/10.1016/j.tet.2022.132930
Tila	Julkaistu - 27 elok. 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Pääsy asiakirjaan

10.1016/j.tet.2022.132930Lisenssi: CC BY

OpenUrl-saatavuus

Koko teksti

Siteeraa tätä

@article{aaeaadc032b141d187cef865a87f371c,

title = "An improved method for synthesis of non-symmetric triarylpyridines",

abstract = "The optimization of a multicomponent reaction, to prepare triarylpyridines (triphenylpyridine), and which includes 17 examples where each aryl substituent is distinct (non-symmetric pyridine) is reported. The non-symmetric triarylpyridine aqrar forming reaction involves the sequential addition of two different acetophenones to a benzylamine in DMF in the presence of copper (I) iodide (20 mol %), methanolic ammonia (2 equiv.), and oxygen. The optimized method was used to give twenty five different triarylpyridines in 43–91% yield, including products with a thiophene substituent and bipyridines.",

keywords = "pyridine synthesis, copper iodide, multicomponent reactors, oxidative elimination",

author = "Arvind Negi and Mirallai, {Styliana I.} and Saidulu Konda and Murphy, {Paul V.}",

year = "2022",

month = aug,

day = "27",

doi = "10.1016/j.tet.2022.132930",

language = "English",

volume = "121",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - An improved method for synthesis of non-symmetric triarylpyridines

AU - Negi, Arvind

AU - Mirallai, Styliana I.

AU - Konda, Saidulu

AU - Murphy, Paul V.

PY - 2022/8/27

Y1 - 2022/8/27

N2 - The optimization of a multicomponent reaction, to prepare triarylpyridines (triphenylpyridine), and which includes 17 examples where each aryl substituent is distinct (non-symmetric pyridine) is reported. The non-symmetric triarylpyridine aqrar forming reaction involves the sequential addition of two different acetophenones to a benzylamine in DMF in the presence of copper (I) iodide (20 mol %), methanolic ammonia (2 equiv.), and oxygen. The optimized method was used to give twenty five different triarylpyridines in 43–91% yield, including products with a thiophene substituent and bipyridines.

AB - The optimization of a multicomponent reaction, to prepare triarylpyridines (triphenylpyridine), and which includes 17 examples where each aryl substituent is distinct (non-symmetric pyridine) is reported. The non-symmetric triarylpyridine aqrar forming reaction involves the sequential addition of two different acetophenones to a benzylamine in DMF in the presence of copper (I) iodide (20 mol %), methanolic ammonia (2 equiv.), and oxygen. The optimized method was used to give twenty five different triarylpyridines in 43–91% yield, including products with a thiophene substituent and bipyridines.

KW - pyridine synthesis

KW - copper iodide

KW - multicomponent reactors

KW - oxidative elimination

U2 - 10.1016/j.tet.2022.132930

DO - 10.1016/j.tet.2022.132930

M3 - Article

SN - 0040-4020

VL - 121

JO - Tetrahedron

JF - Tetrahedron

M1 - 132930

ER -

An improved method for synthesis of non-symmetric triarylpyridines

Abstrakti

Pääsy asiakirjaan

OpenUrl-saatavuus

Sormenjälki

Siteeraa tätä