An electroactive alginate hydrogel nanocomposite reinforced by functionalized graphite nanofilaments for neural tissue engineering

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An electroactive alginate hydrogel nanocomposite reinforced by functionalized graphite nanofilaments for neural tissue engineering. / Homaeigohar, Shahin; Tsai, Ting Yu; Young, Tai Hong; Yang, Hsin Ju; Ji, You Ren.

julkaisussa: Carbohydrate Polymers, Vuosikerta 224, 115112, 01.08.2019.

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

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Bibtex - Lataa

@article{d2ca8ea4c1c948ae827e542789ccb64a,
title = "An electroactive alginate hydrogel nanocomposite reinforced by functionalized graphite nanofilaments for neural tissue engineering",
abstract = "To address the need to biodegradable, electroactive conduits accelerating nerve regeneration, here we develop a nanocomposite hydrogel made of alginate reinforced by citric acid functionalized graphite nanofilaments. The green, simple functionalization enhances the nanofillers distribution and their biocompatibility, as verified using mesenchymal stem cells in vitro. The uniformly distributed nanofilaments raise mechanical stability of the nanocomposite hydrogel versus the neat one up to three times. Also, the nanofilaments enable electrical contact and intercellular signaling thereby stimulating their biological activity. In vitro studies proved the biocompatibility of the nanocomposite hydrogel whereon PC12 cells proliferate and spread evidently. In vivo tests also supported applicability of the nanocomposite hydrogel for implantation within body, and the samples showed no adverse reaction and no inflammatory responses after 14 days. Conclusively, the results certify that the developed electroactive nanocomposite hydrogel is able to stimulate nerve generation and could be confidently used as a nerve conduit material.",
keywords = "Electroactivity, Graphite, Hydrogel, Nerve, Tissue engineering",
author = "Shahin Homaeigohar and Tsai, {Ting Yu} and Young, {Tai Hong} and Yang, {Hsin Ju} and Ji, {You Ren}",
year = "2019",
month = "8",
day = "1",
doi = "10.1016/j.carbpol.2019.115112",
language = "English",
volume = "224",
journal = "Carbohydrate Polymers",
issn = "0144-8617",

}

RIS - Lataa

TY - JOUR

T1 - An electroactive alginate hydrogel nanocomposite reinforced by functionalized graphite nanofilaments for neural tissue engineering

AU - Homaeigohar, Shahin

AU - Tsai, Ting Yu

AU - Young, Tai Hong

AU - Yang, Hsin Ju

AU - Ji, You Ren

PY - 2019/8/1

Y1 - 2019/8/1

N2 - To address the need to biodegradable, electroactive conduits accelerating nerve regeneration, here we develop a nanocomposite hydrogel made of alginate reinforced by citric acid functionalized graphite nanofilaments. The green, simple functionalization enhances the nanofillers distribution and their biocompatibility, as verified using mesenchymal stem cells in vitro. The uniformly distributed nanofilaments raise mechanical stability of the nanocomposite hydrogel versus the neat one up to three times. Also, the nanofilaments enable electrical contact and intercellular signaling thereby stimulating their biological activity. In vitro studies proved the biocompatibility of the nanocomposite hydrogel whereon PC12 cells proliferate and spread evidently. In vivo tests also supported applicability of the nanocomposite hydrogel for implantation within body, and the samples showed no adverse reaction and no inflammatory responses after 14 days. Conclusively, the results certify that the developed electroactive nanocomposite hydrogel is able to stimulate nerve generation and could be confidently used as a nerve conduit material.

AB - To address the need to biodegradable, electroactive conduits accelerating nerve regeneration, here we develop a nanocomposite hydrogel made of alginate reinforced by citric acid functionalized graphite nanofilaments. The green, simple functionalization enhances the nanofillers distribution and their biocompatibility, as verified using mesenchymal stem cells in vitro. The uniformly distributed nanofilaments raise mechanical stability of the nanocomposite hydrogel versus the neat one up to three times. Also, the nanofilaments enable electrical contact and intercellular signaling thereby stimulating their biological activity. In vitro studies proved the biocompatibility of the nanocomposite hydrogel whereon PC12 cells proliferate and spread evidently. In vivo tests also supported applicability of the nanocomposite hydrogel for implantation within body, and the samples showed no adverse reaction and no inflammatory responses after 14 days. Conclusively, the results certify that the developed electroactive nanocomposite hydrogel is able to stimulate nerve generation and could be confidently used as a nerve conduit material.

KW - Electroactivity

KW - Graphite

KW - Hydrogel

KW - Nerve

KW - Tissue engineering

UR - http://www.scopus.com/inward/record.url?scp=85070225636&partnerID=8YFLogxK

U2 - 10.1016/j.carbpol.2019.115112

DO - 10.1016/j.carbpol.2019.115112

M3 - Article

VL - 224

JO - Carbohydrate Polymers

JF - Carbohydrate Polymers

SN - 0144-8617

M1 - 115112

ER -

ID: 36172754