Algorithmic Design of Biomolecular Nanostructures

Julkaisun otsikon käännös: Algorithmic Design of Biomolecular Nanostructures

Abdulmelik Mohammed

Tutkimustuotos: Doctoral ThesisCollection of Articles

Abstrakti

Biomolecular nanotechnology, a field where biomolecules such as DNA and RNA are used as programmable nanoscale construction materials, is emerging as a breakthrough technology with promising applications in nanomedicine, materials science and biophysical research. To accelerate the developments in nucleic acid nanotechnology, general and automated computer aided design tools which enable researchers from different fields to quickly design and synthesize nucleic acid nanostructures could play a significant role. Working in the framework of the robust DNA origami approach, this dissertation presents a novel, highly general and highly automated design approach for the design and synthesis of 2D and polyhedral DNA nanostructures suitable for e.g. biomedical applications. Grounded on graph-theoretic principles, the method introduces an Eulerian tour based approach for topologically routing DNA strands into nanoscale geometries exhibiting complex features. By employing an implementation of the design method, the impact of wireframe architecture on material efficiency and stiffness of DNA nanoscale assemblies was experimentally investigated. Motivated by the design of wireframe DNA nanostructures, we develop an algorithm for finding unknotted DNA strand routings on topologically more complex higher-genus mesh wireframes. Alternatively, cotranscriptionally folding RNA nanostructures have great potential for cell-based mass production of nucleic acid nanostructures. However, the presence of the cotranscriptional complex can present obstacles to folding a target shape. In this dissertation, we propose a graph-theoretic design framework which minimizes the risk of folding traps in a cotranscriptional setting.
Julkaisun otsikon käännösAlgorithmic Design of Biomolecular Nanostructures
AlkuperäiskieliEnglanti
PätevyysTohtorintutkinto
Myöntävä instituutio
  • Aalto-yliopisto
Valvoja/neuvonantaja
  • Orponen, Pekka, Vastuuprofessori
  • Orponen, Pekka, Ohjaaja
Kustantaja
Painoksen ISBN978-952-60-8281-3
Sähköinen ISBN978-952-60-8282-0
TilaJulkaistu - 2018
OKM-julkaisutyyppiG5 Artikkeliväitöskirja

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  • Algorithmic design of cotranscriptionally folding 2D RNA origami structures

    Mohammed, A., Orponen, P. & Pai, S., 31 toukok. 2018, Unconventional Computation and Natural Computation: 17th International Conference, UCNC 2018, Fontainebleau, France, June 25-29, 2018, Proceedings. Stepney, S. & Verlan, S. (toim.). Springer, s. 159-172 (Lecture Notes in Computer Science; Vuosikerta 10867).

    Tutkimustuotos: Artikkeli kirjassa/konferenssijulkaisussaConference article in proceedingsScientificvertaisarvioitu

    Open access
    Tiedosto
    2 Sitaatiot (Scopus)
    253 Lataukset (Pure)
  • Effects of design choices on the stiffness of wireframe DNA origami structures

    Benson, E., Mohammed, A., Rayneau-Kirkhope, D., Gådin, A., Orponen, P. & Högberg, B., 25 syysk. 2018, julkaisussa: ACS Nano. 12, 9, s. 9291-9299 9 Sivumäärä

    Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

    Open access
    Tiedosto
    32 Sitaatiot (Scopus)
    292 Lataukset (Pure)
  • Unknotted strand routings of triangulated meshes

    Mohammed, A. & Hajij, M., 2017, DNA Computing and Molecular Programming: 23rd International Conference, DNA 23, Austin, TX, USA, September 24–28, 2017, Proceedings. Brijder, R. & Qian, L. (toim.). Springer, s. 46-63 ( Lecture Notes in Computer Science; Vuosikerta 10467).

    Tutkimustuotos: Artikkeli kirjassa/konferenssijulkaisussaConference article in proceedingsScientificvertaisarvioitu

    Open access
    Tiedosto
    3 Sitaatiot (Scopus)
    237 Lataukset (Pure)

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