Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences

N. Williams; Cam-CAN

doi:10.1038/ncomms15671

Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences

N. Williams
, Cam-CAN

Ei julkaistu Aalto-yliopiston affiliaatiolla

Medical Research Council
Harvard University
Univ Manchester, Jodrell Bank Centre for Astrophysics, University of Manchester, Sch Phys & Astron, Jodrell Bank Ctr Astrophys
University of Helsinki

Tutkimustuotos: Lehtiartikkeli › Article › Scientific › vertaisarvioitu

53 Sitaatiot (Scopus)

Abstrakti

Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalo-graphic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.

Alkuperäiskieli	Englanti
Artikkeli	15671
Sivumäärä	12
Julkaisu	Nature Communications
Vuosikerta	8
DOI - pysyväislinkit	https://doi.org/10.1038/ncomms15671
Tila	Julkaistu - 9 kesäk. 2017
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Rahoitus

The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) research was supported by the Biotechnology and Biological Sciences Research Council (BB/H008217/1); R.N.H. is additionally supported by the UK Medical Research Council (MC_A060_5PR10); DP is supported by the UK Medical Research Council (MC_A060_5PR13). We are grateful to the Cam-CAN respondents and their primary care teams in Cambridge for their participation in this study. We also thank colleagues at the MRC Cognition and Brain Sciences Unit MEG and MRI facilities for their assistance. Finally, we thank Dr Rousselet and two other reviewers for their helpful comments.

Pääsy asiakirjaan

10.1038/ncomms15671

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title = "Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences",

abstract = "Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalo-graphic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.",

keywords = "COGNITIVE PROCESSING SPEED, GAUSSIAN WATER DIFFUSION, PATTERN, LATENCY, MYELIN, FACES, INFORMATION, PLASTICITY, SYSTEM",

author = "D. Price and Tyler, \{L. K.\} and \{Neto Henriques\}, R. and Campbell, \{K. L.\} and N. Williams and Treder, \{M. S.\} and Taylor, \{J. R.\} and Henson, \{R. N.A.\} and Carol Brayne and Bullmore, \{Edward T.\} and Calder, \{Andrew C.\} and Rhodri Cusack and Tim Dalgleish and John Duncan and Matthews, \{Fiona E.\} and Marslen-Wilson, \{William D.\} and Rowe, \{James B.\} and Shafto, \{Meredith A.\} and Teresa Cheung and Simon Davis and Linda Geerligs and Rogier Kievit and Anna McCarrey and Abdur Mustafa and David Samu and Tsvetanov, \{Kamen A.\} and \{van Belle\}, Janna and Lauren Bates and Tina Emery and Sharon Erzinglioglu and Andrew Gadie and Sofia Gerbase and Stanimira Georgieva and Claire Hanley and Beth Parkin and David Troy and Tibor Auer and Marta Correia and Lu Gao and Emma Green and Jodie Allen and Gillian Amery and Liana Amunts and Anne Barcroft and Amanda Castle and Cheryl Dias and Jonathan Dowrick and Melissa Fair and Hayley Fisher and Anna Goulding and \{Cam-CAN consortium\}",

year = "2017",

month = jun,

day = "9",

doi = "10.1038/ncomms15671",

language = "English",

volume = "8",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences

AU - Price, D.

AU - Tyler, L. K.

AU - Neto Henriques, R.

AU - Campbell, K. L.

AU - Williams, N.

AU - Treder, M. S.

AU - Taylor, J. R.

AU - Henson, R. N.A.

AU - Brayne, Carol

AU - Bullmore, Edward T.

AU - Calder, Andrew C.

AU - Cusack, Rhodri

AU - Dalgleish, Tim

AU - Duncan, John

AU - Matthews, Fiona E.

AU - Marslen-Wilson, William D.

AU - Rowe, James B.

AU - Shafto, Meredith A.

AU - Cheung, Teresa

AU - Davis, Simon

AU - Geerligs, Linda

AU - Kievit, Rogier

AU - McCarrey, Anna

AU - Mustafa, Abdur

AU - Samu, David

AU - Tsvetanov, Kamen A.

AU - van Belle, Janna

AU - Bates, Lauren

AU - Emery, Tina

AU - Erzinglioglu, Sharon

AU - Gadie, Andrew

AU - Gerbase, Sofia

AU - Georgieva, Stanimira

AU - Hanley, Claire

AU - Parkin, Beth

AU - Troy, David

AU - Auer, Tibor

AU - Correia, Marta

AU - Gao, Lu

AU - Green, Emma

AU - Allen, Jodie

AU - Amery, Gillian

AU - Amunts, Liana

AU - Barcroft, Anne

AU - Castle, Amanda

AU - Dias, Cheryl

AU - Dowrick, Jonathan

AU - Fair, Melissa

AU - Fisher, Hayley

AU - Goulding, Anna

AU - Cam-CAN consortium

PY - 2017/6/9

Y1 - 2017/6/9

N2 - Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalo-graphic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.

AB - Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalo-graphic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.

KW - COGNITIVE PROCESSING SPEED

KW - GAUSSIAN WATER DIFFUSION

KW - PATTERN

KW - LATENCY

KW - MYELIN

KW - FACES

KW - INFORMATION

KW - PLASTICITY

KW - SYSTEM

U2 - 10.1038/ncomms15671

DO - 10.1038/ncomms15671

M3 - Article

C2 - 28598417

SN - 2041-1723

VL - 8

JO - Nature Communications

JF - Nature Communications

M1 - 15671

ER -

Age-related delay in visual and auditory evoked responses is mediated by white- and grey-matter differences

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