Active diffusion of nanoparticles of maternal origin within the embryonic brain

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Tutkijat

  • Mikhail Yuryev
  • Mónica Pa Ferreira
  • Vimalkumar Balasubramanian
  • Alexandra Mr Correia
  • Ermei M. Mäkilä
  • Ville Jokinen
  • Liliia Andriichuk
  • Marianna Kemell
  • Jarno J. Salonen
  • Jouni T. Hirvonen
  • Hélder A. Santos
  • Claudio Rivera

Organisaatiot

  • University of Helsinki
  • University of Turku
  • Institut de Neurobiologie de la Méditerranée
  • Aix-Marseille Université

Kuvaus

Aim: To investigate porous silicon (PSi) nanoparticles (NPs) behavior in the embryonic brain. Materials & methods: Fluorescently labeled PSi NPs were injected into the embryonic brains intraventricularly and to the mother intravenously (iv.). Brain histology from different time points up to 3 days was analyzed and live brains imaged with two-photon microscopy. Results: PSi NPs were able to penetrate 80% of the embryonic cortical depth. Particle motility was confirmed in real-time in vivo. PSi NPs were able to penetrate the embryonic cortex after either iv. maternal or intraventricular injection. No developmental of macromorphological changes or increased cell apoptosis was observed. Conclusion: PSi NPs penetrate deep in the brain tissues of embryos after intraventricular injection and after iv. injection to the mother.

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut2471-2481
Sivumäärä11
JulkaisuNanomedicine
Vuosikerta11
Numero19
TilaJulkaistu - 1 lokakuuta 2016
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 9793845