2.5D Hierarchical Structuring of Nanocomposite Hydrogel Films Containing Cellulose Nanocrystals

Tutkimustuotos: Lehtiartikkelivertaisarvioitu

Tutkijat

  • Kevin J. De France
  • Mouhanad Babi
  • Jaana Vapaavuori

  • Todd Hoare
  • Jose Moran-Mirabal
  • Emily D. Cranston

Organisaatiot

  • McMaster University
  • University of Montreal
  • University of British Columbia

Kuvaus

Although two-dimensional hydrogel thin films have been applied across many biomedical applications, creating higher dimensionality structured hydrogel interfaces would enable potentially improved and more biomimetic hydrogel performance in biosensing, bioseparations, tissue engineering, drug delivery, and wound healing applications. Herein, we present a new and simple approach to control the structure of hydrogel thin films in 2.5D. Hybrid suspensions containing cellulose nanocrystals (CNCs) and aldehyde- or hydrazide-functionalized poly(oligoethylene glycol methacrylate) (POEGMA) were spin-coated onto prestressed polystyrene substrates to form cross-linked hydrogel thin films. The films were then structured via thermal shrinking, with control over the direction of shrinking leading to the formation of biaxial, uniaxial, or hierarchical wrinkles. Notably, POEGMA-only hydrogel thin films (without CNCs) did not form uniform wrinkles due to partial dewetting from the substrate during shrinking. Topographical feature sizes of CNC POEGMA films could be tuned across 2 orders of magnitude (from 300 nm to 20 kern) by varying the POEGMA concentration, the length of poly(ethylene glycol) side chains in the polymer, and/or the overall film thickness. Furthermore, by employing adhesive masks during the spin-coating process, structured films with gradient wrinkle sizes can be fabricated. This precise control over both wrinkle size and wrinkle topography adds a level of functionality that to date has been lacking in conventional hydrogel networks.

Yksityiskohdat

AlkuperäiskieliEnglanti
Sivut6325-6335
Sivumäärä11
JulkaisuACS Applied Materials and Interfaces
Vuosikerta11
Numero6
TilaJulkaistu - 1 tammikuuta 2019
OKM-julkaisutyyppiA1 Julkaistu artikkeli, soviteltu

ID: 32394039