Supporting Information for How to Predict the pKa of Any Compound in Any Solvent: Structures

  • Michael Busch (Creator)
  • Ernst Ahlberg (Creator)
  • Elisabet Ahlberg (Creator)
  • Kari Laasonen (Creator)

Tietoaineisto

Description

Final structures in xyz format (ZIP)

Acid–base properties of molecules in nonaqueous solvents are of critical importance for almost all areas of chemistry. Despite this very high relevance, our knowledge is still mostly limited to the pKa of rather few compounds in the most common solvents, and a simple yet truly general computational procedure to predict pKa’s of any compound in any solvent is still missing. In this contribution, we describe such a procedure. Our method requires only the experimental pKa of a reference compound in water and a few standard quantum-chemical calculations. This method is tested through computing the proton solvation energy in 39 solvents and by comparing the pKa of 142 simple compounds in 12 solvents. Our computations indicate that the method to compute the proton solvation energy is robust with respect to the detailed computational setup and the construction of the solvation model. The unscaled pKa’s computed using an implicit solvation model on the other hand differ significantly from the experimental data. These differences are partly associated with the poor quality of the experimental data and the well-known shortcomings of implicit solvation models. General linear scaling relationships to correct this error are suggested for protic and aprotic media. Using these relationships, the deviations between experiment and computations drop to a level comparable to that observed in water, which highlights the efficiency of our method.
Koska saatavilla9 toukok. 2022
Julkaisijafigshare

Dataset Licences

  • CC-BY-NC-4.0
  • How to Predict the pKof Any Compound in Any Solvent

    Busch, M., Ahlberg, E., Ahlberg, E. & Laasonen, K., 24 toukok. 2022, julkaisussa: ACS Omega. 7, 20, s. 17369–17383

    Tutkimustuotos: LehtiartikkeliArticleScientificvertaisarvioitu

    Open access
    Tiedosto
    19 Sitaatiot (Scopus)
    1341 Lataukset (Pure)

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