Data from: Single-cell genomics reveals hundreds of coexisting subpopulations in wild Prochlorococcus



Extensive genomic diversity within coexisting members of a microbial species has been revealed through selected cultured isolates and metagenomic assemblies. Yet, the cell-by-cell genomic composition of wild uncultured populations of co-occurring cells is largely unknown. In this work, we applied large-scale single-cell genomics to study populations of the globally abundant marine cyanobacterium Prochlorococcus. We show that they are composed of hundreds of subpopulations with distinct “genomic backbones,” each backbone consisting of a different set of core gene alleles linked to a small distinctive set of flexible genes. These subpopulations are estimated to have diverged at least a few million years ago, suggesting ancient, stable niche partitioning. Such a large set of coexisting subpopulations may be a general feature of free-living bacterial species with huge populations in highly mixed habitats.
Saatavilla25 huhtikuuta 2014
JulkaisijaDryad Digital Repository



  • Nadav Kashtan (Contributor)
  • Sara E. Roggensack (Contributor)
  • Sébastien Rodrigue (Contributor)
  • Jessie W. Thompson (Contributor)
  • Steven J. Biller (Contributor)
  • Allison Coe (Contributor)
  • Huiming Ding (Contributor)
  • Pekka Marttinen (Creator)
  • Rex R. Malmstrom (Contributor)
  • Roman Stocker (Contributor)
  • MJ Follows (Contributor)
  • R Stepanauskas (Creator)
  • Chisholm SW (Creator)

ID: 21290876