YEAST EXPRESSING CELLULASES FOR SIMULTANEOUS SACCHARIFICATION AND FERMENTATION USING CELLULOSE

JOHN MCBRIDE (Inventor), ELENA BREVNOVA (Inventor), MARK MELLON (Inventor), ALLAN FROEHLICH (Inventor), KRISTEN DELEAULT (Inventor), VINEET RAJGARHIA (Inventor), RIAAN DEN HAAN (Inventor), Merja Penttilä (Inventor), MARJA ILMEN (Inventor), MATTI SIIKA-AHO (Inventor), JAANA UUSITALO (Inventor), A STONEHOUSE EMILY (Inventor), ALAN GILBERT (Inventor), HAOWEN XU (Inventor), DEIDRE WILLES (Inventor), JOHN BARDSLEY (Inventor), ANU KOIVULA (Inventor), SANNI VOUTILAINEN (Inventor)

Research output: Patent

Abstract

The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol from cellulose. According to the invention, host cells expressing a combination of heterologous cellulases can be used to produce ethanol from cellulose. In addition, multiple host cells expressing different heterlogous cellulases can be co-cultured together and used to produce ethanol from cellulose. Furthermore, the invention demonstrates for the first time the ability of Kluveryomyces to produce ethanol from cellulose. The yeast strains and co-cultures of yeast strains of the invention can be used to produce ethanol on their own, or can also be used in combination with externally added cellulases to increase the efficiency of saccharification and fermentation processes.

Original languageEnglish
Patent numberUS2016010117
IPCC12N 9/ 42 A I
Priority date01/07/2015
Publication statusPublished - 14 Jan 2016
MoE publication typeH1 Granted patent

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    MCBRIDE, JOHN., BREVNOVA, ELENA., MELLON, MARK., FROEHLICH, ALLAN., DELEAULT, KRISTEN., RAJGARHIA, VINEET., ... VOUTILAINEN, SANNI. (2016). IPC No. C12N 9/ 42 A I. YEAST EXPRESSING CELLULASES FOR SIMULTANEOUS SACCHARIFICATION AND FERMENTATION USING CELLULOSE. (Patent No. US2016010117).