Visual Stimuli Modulate Local Field Potentials But Drive No High-Frequency Activity in Human Auditory Cortex

Jyrki Ahveninen*, Hsin Ju Lee, Hsiang Yu Yu, Cheng Chia Lee, Chien Chen Chou, Seppo P. Ahlfors, Wen Jui Kuo, Iiro P. Jääskeläinen, Fa Hsuan Lin

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)

Abstract

Neuroimaging studies suggest cross-sensory visual influences in human auditory cortices (ACs). Whether these influences reflect active visual processing in human ACs, which drives neuronal firing and concurrent broadband high-frequency activity (BHFA; >70 Hz), or whether they merely modulate sound processing is still debatable. Here, we presented auditory, visual, and audiovisual stimuli to 16 participants (7 women, 9 men) with stereo-EEG depth electrodes implanted near ACs for presurgical monitoring. Anatomically normalized group analyses were facilitated by inverse modeling of intracranial source currents. Analyses of intracranial event-related potentials (iERPs) suggested cross-sensory responses to visual stimuli in ACs, which lagged the earliest auditory responses by several tens of milliseconds. Visual stimuli also modulated the phase of intrinsic low-frequency oscillations and triggered 15–30 Hz event-related desynchronization in ACs. However, BHFA, a putative correlate of neuronal firing, was not significantly increased in ACs after visual stimuli, not even when they coincided with auditory stimuli. Intracranial recordings demonstrate cross-sensory modulations, but no indication of active visual processing in human ACs.

Original languageEnglish
Article numbere0890232023
JournalJOURNAL OF NEUROSCIENCE
Volume44
Issue number7
DOIs
Publication statusPublished - 14 Feb 2024
MoE publication typeA1 Journal article-refereed

Keywords

  • auditory
  • cross-modal
  • ECoG
  • EEG
  • multisensory
  • SEEG

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