Viral pathogenesis of SARS-CoV-2 infection and male reproductive health

Shubhadeep Roychoudhury, Anandan Das, Niraj Kumar Jha, Kavindra Kumar Kesari, Shatabhisha Roychoudhury, Saurabh Kumar Jha, Raghavender Kosgi, Arun Paul Choudhury, Norbert Lukac, Nithar Ranjan Madhu, Dhruv Kumar, Petr Slama

Research output: Contribution to journalArticleScientificpeer-review

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Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted.

Original languageEnglish
Article number200347
Pages (from-to)200347
Number of pages11
Issue number1
Publication statusPublished - 20 Jan 2021
MoE publication typeA1 Journal article-refereed


  • ACE2
  • COVID-19
  • fertility
  • male reproduction
  • SARS-CoV-2 infection
  • testicular damage


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