Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality

Research output: Contribution to journalArticleScientificpeer-review

Standard

Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality. / Pearce, Eiluned; Wlodarski, Rafael; Machin, Anna; Dunbar, Robin I.M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 20, 16.05.2017, p. 5300-5305.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

APA

Vancouver

Author

Bibtex - Download

@article{aa9ad033a209484fba0746d6611d1caf,
title = "Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality",
abstract = "There is growing evidence that the number and quality of social relationships have substantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fitness. Although it is widely recognized that these outcomes are mediated by a number of neuropeptides, the roles these play remain debated. We suggest that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish between different social domains, has obscured the complexity involved.We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relation to three separate domains of sociality (social disposition, dyadic relationships, and social networks) to show that three neuropeptides (β-endorphin, oxytocin, and dopamine) play particularly important roles, with each being associated predominantly with a different social domain. However, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive relationships and often do not survive control for other neuropeptides). In contrast, vasopressin, serotonin, and testosterone play only limited roles.",
keywords = "Empathy, Genetics, Romantic relationships, Social networks, Social neuropeptides",
author = "Eiluned Pearce and Rafael Wlodarski and Anna Machin and Dunbar, {Robin I.M.}",
year = "2017",
month = "5",
day = "16",
doi = "10.1073/pnas.1700712114",
language = "English",
volume = "114",
pages = "5300--5305",
journal = "Proceedings of the National Academy of Sciences",
issn = "0027-8424",
number = "20",

}

RIS - Download

TY - JOUR

T1 - Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality

AU - Pearce, Eiluned

AU - Wlodarski, Rafael

AU - Machin, Anna

AU - Dunbar, Robin I.M.

PY - 2017/5/16

Y1 - 2017/5/16

N2 - There is growing evidence that the number and quality of social relationships have substantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fitness. Although it is widely recognized that these outcomes are mediated by a number of neuropeptides, the roles these play remain debated. We suggest that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish between different social domains, has obscured the complexity involved.We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relation to three separate domains of sociality (social disposition, dyadic relationships, and social networks) to show that three neuropeptides (β-endorphin, oxytocin, and dopamine) play particularly important roles, with each being associated predominantly with a different social domain. However, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive relationships and often do not survive control for other neuropeptides). In contrast, vasopressin, serotonin, and testosterone play only limited roles.

AB - There is growing evidence that the number and quality of social relationships have substantial impacts on health, well-being, and longevity, and, at least in animals, on reproductive fitness. Although it is widely recognized that these outcomes are mediated by a number of neuropeptides, the roles these play remain debated. We suggest that an overemphasis on one neuropeptide (oxytocin), combined with a failure to distinguish between different social domains, has obscured the complexity involved.We use variation in 33 SNPs for the receptor genes for six well-known social neuropeptides in relation to three separate domains of sociality (social disposition, dyadic relationships, and social networks) to show that three neuropeptides (β-endorphin, oxytocin, and dopamine) play particularly important roles, with each being associated predominantly with a different social domain. However, endorphins and dopamine have a much wider compass than oxytocin (whose effects are confined to romantic/reproductive relationships and often do not survive control for other neuropeptides). In contrast, vasopressin, serotonin, and testosterone play only limited roles.

KW - Empathy

KW - Genetics

KW - Romantic relationships

KW - Social networks

KW - Social neuropeptides

UR - http://www.scopus.com/inward/record.url?scp=85019856183&partnerID=8YFLogxK

U2 - 10.1073/pnas.1700712114

DO - 10.1073/pnas.1700712114

M3 - Article

VL - 114

SP - 5300

EP - 5305

JO - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

SN - 0027-8424

IS - 20

ER -

ID: 13643124