Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans
Research output: Contribution to journal › Article › Scientific › peer-review
Researchers
Research units
- Broad Institute
- Harvard School of Public Health
- Novartis USA
- Tampere University Hospital
- Massachusetts General Hospital
- University of Tartu
- Russian Ministry of Health
- Petrozavodsk State University
- Folkhalsan
- Harvard Medical School
- Helsinki University Central Hospital
- Jorvi Hospital
- Tartu University Hospital
- University of Turku
- University of Eastern Finland
- National Institute for Health and Welfare
- Tampere University
- University of Helsinki
- Massachusetts Institute of Technology
Abstract
According to the hygiene hypothesis, the increasing incidence of autoimmune diseases in western countries may be explained by changes in early microbial exposure, leading to altered immune maturation. We followed gut microbiome development from birth until age three in 222 infants in Northern Europe, where early-onset autoimmune diseases are common in Finland and Estonia but are less prevalent in Russia. We found that Bacteroides species are lowly abundant in Russians but dominate in Finnish and Estonian infants. Therefore, their lipopolysaccharide (LPS) exposures arose primarily from Bacteroides rather than from Escherichia coli, which is a potent innate immune activator. We show that Bacteroides LPS is structurally distinct from E. coli LPS and inhibits innate immune signaling and endotoxin tolerance; furthermore, unlike LPS from E. coli, B. dorei LPS does not decrease incidence of autoimmune diabetes in non-obese diabetic mice. Early colonization by immunologically silencing microbiota may thus preclude aspects of immune education.
Details
Original language | English |
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Pages (from-to) | 842-853 |
Number of pages | 12 |
Journal | CELL |
Volume | 165 |
Issue number | 4 |
Publication status | Published - 5 May 2016 |
MoE publication type | A1 Journal article-refereed |
ID: 3347742