Validating an SVM-based neonatal seizure detection algorithm for generalizability, non-inferiority and clinical efficacy

Karoliina T. Tapani*, P. Nevalainen, Sampsa Vanhatalo, Nathan J. Stevenson

*Corresponding author for this work

Research output: Contribution to journalArticleScientificpeer-review

1 Citation (Scopus)
14 Downloads (Pure)

Abstract

Neonatal seizure detection algorithms (SDA) are approaching the benchmark of human expert annotation. Measures of algorithm generalizability and non-inferiority as well as measures of clinical efficacy are needed to assess the full scope of neonatal SDA performance. We validated our neonatal SDA on an independent data set of 28 neonates. Generalizability was tested by comparing the performance of the original training set (cross-validation) to its performance on the validation set. Non-inferiority was tested by assessing inter-observer agreement between combinations of SDA and two human expert annotations. Clinical efficacy was tested by comparing how the SDA and human experts quantified seizure burden and identified clinically significant periods of seizure activity in the EEG. Algorithm performance was consistent between training and validation sets with no significant worsening in AUC (p > 0.05, n = 28). SDA output was inferior to the annotation of the human expert, however, re-training with an increased diversity of data resulted in non-inferior performance (Δκ = 0.077, 95% CI: −0.002-0.232, n = 18). The SDA assessment of seizure burden had an accuracy ranging from 89 to 93%, and 87% for identifying periods of clinical interest. The proposed SDA is approaching human equivalence and provides a clinically relevant interpretation of the EEG.

Original languageEnglish
Article number105399
Pages (from-to)1-10
Number of pages10
JournalCOMPUTERS IN BIOLOGY AND MEDICINE
Volume145
DOIs
Publication statusPublished - Jun 2022
MoE publication typeA1 Journal article-refereed

Keywords

  • EEG monitoring
  • neonatal EEG
  • Neonatal intensive care unit
  • Seizure
  • Support vector machine

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