Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics

Mady Elbahri; Ramzy Abdelaziz; Duygu Disci-Zayed; Shahin Homaeigohar; Justyna Sosna; Dieter Adam; Lorenz Kienle; Torben Dankwort; Moheb Abdelaziz

doi:10.1038/ncomms15319

Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics

Mady Elbahri, Ramzy Abdelaziz, Duygu Disci-Zayed, Shahin Homaeigohar, Justyna Sosna, Dieter Adam, Lorenz Kienle, Torben Dankwort, Moheb Abdelaziz^*

^*Corresponding author for this work

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Abstract

The dynamic underwater chemistry seen in nature is inspiring for the next generation of eco-friendly nanochemistry. In this context, green synthesis of size-tailored nanoparticles in a facile and scalable manner via a dynamic process is an interesting challenge. Simulating the volcano-induced dynamic chemistry of the deep ocean, here we demonstrate the Leidenfrost dynamic chemistry occurring in an underwater overheated confined zone as a new tool for customized creation of nanoclusters of zinc peroxide. The hydrodynamic nature of the phenomenon ensures eruption of the nanoclusters towards a much colder region, giving rise to growth of monodisperse, size-tailored nanoclusters. Such nanoparticles are investigated in terms of their cytotoxicity on suspension and adherent cells to prove their applicability as cancer nanotherapeutics. Our research can pave the way for employment of the dynamic green nanochemistry in facile, scalable fabrication of size-tailored nanoparticles for biomedical applications.

Original language	English
Article number	15319
Journal	Nature Communications
Volume	8
DOIs	https://doi.org/10.1038/ncomms15319
Publication status	Published - 12 May 2017
MoE publication type	A1 Journal article-refereed

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10.1038/ncomms15319

Elbahri et al 2017-Underwater Leidenfrost nanochemistryFinal published version, 3.77 MBLicence: CC BY

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AU - Homaeigohar, Shahin

AU - Sosna, Justyna

AU - Adam, Dieter

AU - Kienle, Lorenz

AU - Dankwort, Torben

AU - Abdelaziz, Moheb

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Underwater Leidenfrost nanochemistry for creation of size-tailored zinc peroxide cancer nanotherapeutics

Abstract

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