Abstract
Mechanical loading plays a crucial role throughout humans’ lifetime since their embryonic development up to the tissues’ homeostasis. Depending on the cell type and location, these mechanical stimuli regulate specific cell functions,
namely gene expression, cell growth, differentiation and death. Cells are highly dynamic and it still remains unclear how cells sense these forces and convert them into biochemical responses. This review aims to provide an introductory research of the load-sensitive cells’ mechanobiology present in the bone tissue. Subsequently, this study will contribute to design novel orthopedic implants that overcome their current impaired fixation to the natural bone.
namely gene expression, cell growth, differentiation and death. Cells are highly dynamic and it still remains unclear how cells sense these forces and convert them into biochemical responses. This review aims to provide an introductory research of the load-sensitive cells’ mechanobiology present in the bone tissue. Subsequently, this study will contribute to design novel orthopedic implants that overcome their current impaired fixation to the natural bone.
Original language | English |
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Title of host publication | Resumos alargados do 8º Congresso Nacional de Biomecânica |
Subtitle of host publication | 15 e 16 de fevereiro de 2019, Unhais da Serra, Covilhã |
Editors | António Completo, António Ramos, Aurélio Faria |
Place of Publication | Aveiro |
Publisher | Universidade de Aveiro |
Pages | 189-190 |
Edition | 1 |
ISBN (Electronic) | 978-972-789-586-1 |
Publication status | Published - 12 Mar 2019 |
MoE publication type | A4 Conference publication |
Event | Congresso Nacional de Biomecânica - Covilhã, Portugal Duration: 15 Feb 2019 → 16 Feb 2019 Conference number: 8 |
Conference
Conference | Congresso Nacional de Biomecânica |
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Country/Territory | Portugal |
City | Covilhã |
Period | 15/02/2019 → 16/02/2019 |
Keywords
- mechanobiology
- mechanosensing
- mechanotransduction
- orthopedic implants