Understanding mechanobiology – Linking the mechanical stimulation to cellular response

F. Melo-Fonseca, Ines Mendes Pinto, Michael Gasik, Filipe Samuel Silva, G. Miranda

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

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Mechanical loading plays a crucial role throughout humans’ lifetime since their embryonic development up to the tissues’ homeostasis. Depending on the cell type and location, these mechanical stimuli regulate specific cell functions,
namely gene expression, cell growth, differentiation and death. Cells are highly dynamic and it still remains unclear how cells sense these forces and convert them into biochemical responses. This review aims to provide an introductory research of the load-sensitive cells’ mechanobiology present in the bone tissue. Subsequently, this study will contribute to design novel orthopedic implants that overcome their current impaired fixation to the natural bone.
Original languageEnglish
Title of host publicationResumos alargados do 8º Congresso Nacional de Biomecânica
Subtitle of host publication15 e 16 de fevereiro de 2019, Unhais da Serra, Covilhã
EditorsAntónio Completo, António Ramos, Aurélio Faria
Place of PublicationAveiro
PublisherUniversidade de Aveiro
ISBN (Electronic)978-972-789-586-1
Publication statusPublished - 12 Mar 2019
MoE publication typeA4 Article in a conference publication
EventCongresso Nacional de Biomecânica - Covilhã, Portugal
Duration: 15 Feb 201916 Feb 2019
Conference number: 8


ConferenceCongresso Nacional de Biomecânica


  • mechanobiology
  • mechanosensing
  • mechanotransduction
  • orthopedic implants


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