Understanding mechanobiology – Linking the mechanical stimulation to cellular response

F. Melo-Fonseca; Ines Mendes Pinto; Michael Gasik; Filipe Samuel Silva; G. Miranda

Understanding mechanobiology – Linking the mechanical stimulation to cellular response

F. Melo-Fonseca, Ines Mendes Pinto, Michael Gasik, Filipe Samuel Silva, G. Miranda

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

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Abstract

Mechanical loading plays a crucial role throughout humans’ lifetime since their embryonic development up to the tissues’ homeostasis. Depending on the cell type and location, these mechanical stimuli regulate specific cell functions,
namely gene expression, cell growth, differentiation and death. Cells are highly dynamic and it still remains unclear how cells sense these forces and convert them into biochemical responses. This review aims to provide an introductory research of the load-sensitive cells’ mechanobiology present in the bone tissue. Subsequently, this study will contribute to design novel orthopedic implants that overcome their current impaired fixation to the natural bone.

Original language	English
Title of host publication	Resumos alargados do 8º Congresso Nacional de Biomecânica
Subtitle of host publication	15 e 16 de fevereiro de 2019, Unhais da Serra, Covilhã
Editors	António Completo, António Ramos, Aurélio Faria
Place of Publication	Aveiro
Publisher	Universidade de Aveiro
Pages	189-190
Edition	1
ISBN (Electronic)	978-972-789-586-1
Publication status	Published - 12 Mar 2019
MoE publication type	A4 Article in a conference publication
Event	Congresso Nacional de Biomecânica - Covilhã, Portugal Duration: 15 Feb 2019 → 16 Feb 2019 Conference number: 8

Conference

Conference	Congresso Nacional de Biomecânica
Country	Portugal
City	Covilhã
Period	15/02/2019 → 16/02/2019

Keywords

mechanobiology
mechanosensing
mechanotransduction
orthopedic implants

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CHEM-Melo-Fonseca-Mendes Pinto-Gasik-Silva-Miranda-2019-Understanding mechanobiologyFinal published version, 1.29 MBLicence: Unspecified

https://ria.ua.pt/handle/10773/25495Licence: Unspecified
http://hdl.handle.net/10773/25495Licence: Unspecified

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Melo-Fonseca, F., Mendes Pinto, I., Gasik, M., Silva, F. S., & Miranda, G. (2019). Understanding mechanobiology – Linking the mechanical stimulation to cellular response. In A. Completo, A. Ramos, & A. Faria (Eds.), Resumos alargados do 8º Congresso Nacional de Biomecânica: 15 e 16 de fevereiro de 2019, Unhais da Serra, Covilhã (1 ed., pp. 189-190). Universidade de Aveiro. https://ria.ua.pt/handle/10773/25495

Melo-Fonseca, F. ; Mendes Pinto, Ines ; Gasik, Michael ; Silva, Filipe Samuel ; Miranda, G. / Understanding mechanobiology – Linking the mechanical stimulation to cellular response. Resumos alargados do 8º Congresso Nacional de Biomecânica: 15 e 16 de fevereiro de 2019, Unhais da Serra, Covilhã. editor / António Completo ; António Ramos ; Aurélio Faria. 1. ed. Aveiro : Universidade de Aveiro, 2019. pp. 189-190

@inproceedings{5b336a43639347c39119fa9958e7c26b,

title = "Understanding mechanobiology – Linking the mechanical stimulation to cellular response",

abstract = "Mechanical loading plays a crucial role throughout humans{\textquoteright} lifetime since their embryonic development up to the tissues{\textquoteright} homeostasis. Depending on the cell type and location, these mechanical stimuli regulate specific cell functions,namely gene expression, cell growth, differentiation and death. Cells are highly dynamic and it still remains unclear how cells sense these forces and convert them into biochemical responses. This review aims to provide an introductory research of the load-sensitive cells{\textquoteright} mechanobiology present in the bone tissue. Subsequently, this study will contribute to design novel orthopedic implants that overcome their current impaired fixation to the natural bone.",

keywords = "mechanobiology, mechanosensing, mechanotransduction, orthopedic implants",

author = "F. Melo-Fonseca and {Mendes Pinto}, Ines and Michael Gasik and Silva, {Filipe Samuel} and G. Miranda",

year = "2019",

month = mar,

day = "12",

language = "English",

pages = "189--190",

editor = "Ant{\'o}nio Completo and Ant{\'o}nio Ramos and Aur{\'e}lio Faria",

booktitle = "Resumos alargados do 8º Congresso Nacional de Biomec{\^a}nica",

publisher = "Universidade de Aveiro",

address = "Portugal",

edition = "1",

note = "Congresso Nacional de Biomec{\^a}nica ; Conference date: 15-02-2019 Through 16-02-2019",

}

Melo-Fonseca, F, Mendes Pinto, I, Gasik, M, Silva, FS & Miranda, G 2019, Understanding mechanobiology – Linking the mechanical stimulation to cellular response. in A Completo, A Ramos & A Faria (eds), Resumos alargados do 8º Congresso Nacional de Biomecânica: 15 e 16 de fevereiro de 2019, Unhais da Serra, Covilhã. 1 edn, Universidade de Aveiro, Aveiro, pp. 189-190, Congresso Nacional de Biomecânica, Covilhã, Portugal, 15/02/2019. <https://ria.ua.pt/handle/10773/25495>

Understanding mechanobiology – Linking the mechanical stimulation to cellular response. / Melo-Fonseca, F.; Mendes Pinto, Ines; Gasik, Michael; Silva, Filipe Samuel; Miranda, G.

Resumos alargados do 8º Congresso Nacional de Biomecânica: 15 e 16 de fevereiro de 2019, Unhais da Serra, Covilhã. ed. / António Completo; António Ramos; Aurélio Faria. 1. ed. Aveiro : Universidade de Aveiro, 2019. p. 189-190.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

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AU - Mendes Pinto, Ines

AU - Gasik, Michael

AU - Silva, Filipe Samuel

AU - Miranda, G.

N1 - Conference code: 8

PY - 2019/3/12

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N2 - Mechanical loading plays a crucial role throughout humans’ lifetime since their embryonic development up to the tissues’ homeostasis. Depending on the cell type and location, these mechanical stimuli regulate specific cell functions,namely gene expression, cell growth, differentiation and death. Cells are highly dynamic and it still remains unclear how cells sense these forces and convert them into biochemical responses. This review aims to provide an introductory research of the load-sensitive cells’ mechanobiology present in the bone tissue. Subsequently, this study will contribute to design novel orthopedic implants that overcome their current impaired fixation to the natural bone.

AB - Mechanical loading plays a crucial role throughout humans’ lifetime since their embryonic development up to the tissues’ homeostasis. Depending on the cell type and location, these mechanical stimuli regulate specific cell functions,namely gene expression, cell growth, differentiation and death. Cells are highly dynamic and it still remains unclear how cells sense these forces and convert them into biochemical responses. This review aims to provide an introductory research of the load-sensitive cells’ mechanobiology present in the bone tissue. Subsequently, this study will contribute to design novel orthopedic implants that overcome their current impaired fixation to the natural bone.

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KW - mechanosensing

KW - mechanotransduction

KW - orthopedic implants

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ER -