Understanding lignin aggregation processes. A case study: Budesonide entrapment and stimuli controlled release from lignin nanoparticles

Mika Henrikki Sipponen, Heiko Lange, Mariko Ago, Claudia Crestini

Research output: Contribution to journalArticleScientificpeer-review

39 Citations (Scopus)
97 Downloads (Pure)

Abstract

The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation was found to follow a kinetically controlled nucleation-growth mechanism in which large lignin molecules formed the initial critical nuclei. Using this information, we demonstrate entrapment of budesonide in LNPs and subsequent pH-triggered and surfactant-responsive release of this synthetic anti-inflammatory corticosteroid. Overall, our results not only provide a promising intestinal delivery system for budesonide, but also deliver fundamental mechanistic understanding for the entrapment of actives in LNPs with controlled size and release properties.

Original languageEnglish
Pages (from-to)9342-9351
JournalACS Sustainable Chemistry and Engineering
Volume6
Issue number7
DOIs
Publication statusPublished - 2018
MoE publication typeA1 Journal article-refereed

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  • Projects

    Scalable manufacturing of lignin-based functional materials for industrial applications

    Sipponen, M.

    01/09/201623/09/2019

    Project: Academy of Finland: Other research funding

    Equipment

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