Understanding lignin aggregation processes. A case study: Budesonide entrapment and stimuli controlled release from lignin nanoparticles

Research output: Contribution to journalArticle


  • Mika Henrikki Sipponen
  • Heiko Lange
  • Mariko Ago
  • Claudia Crestini

Research units

  • University of Rome Tor Vergata


The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation was found to follow a kinetically controlled nucleation-growth mechanism in which large lignin molecules formed the initial critical nuclei. Using this information, we demonstrate entrapment of budesonide in LNPs and subsequent pH-triggered and surfactant-responsive release of this synthetic anti-inflammatory corticosteroid. Overall, our results not only provide a promising intestinal delivery system for budesonide, but also deliver fundamental mechanistic understanding for the entrapment of actives in LNPs with controlled size and release properties.


Original languageEnglish
Pages (from-to)9342-9351
JournalACS Sustainable Chemistry and Engineering
Issue number7
Publication statusPublished - 2018
MoE publication typeA1 Journal article-refereed

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