Understanding lignin aggregation processes. A case study: Budesonide entrapment and stimuli controlled release from lignin nanoparticles
Research output: Contribution to journal › Article
- University of Rome Tor Vergata
The mechanism of lignin nanoprecipitation and subsequent self-assembly was elucidated by studying generation of lignin nanoparticles (LNPs) from aqueous ethanol. LNP formation was found to follow a kinetically controlled nucleation-growth mechanism in which large lignin molecules formed the initial critical nuclei. Using this information, we demonstrate entrapment of budesonide in LNPs and subsequent pH-triggered and surfactant-responsive release of this synthetic anti-inflammatory corticosteroid. Overall, our results not only provide a promising intestinal delivery system for budesonide, but also deliver fundamental mechanistic understanding for the entrapment of actives in LNPs with controlled size and release properties.
|Journal||ACS Sustainable Chemistry and Engineering|
|Publication status||Published - 2018|
|MoE publication type||A1 Journal article-refereed|