Understanding biomaterial-tissue interface quality: combined in vitro evaluation

Michael Gasik*

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

21 Citations (Scopus)
73 Downloads (Pure)

Abstract

One of the greatest challenges in the development of new medical products and devices remains in providing maximal patient safety, efficacy and suitability for the purpose. A ‘good quality’ of the tissue-implant interface is one of the most critical factors for the success of the implant integration. In this paper this challenge is being discussed from the point of view of basic stimuli combination to experimental testing. The focus is in particular on bacterial effects on tissue-implant interaction (for different materials). The demonstration of the experimental evaluation of the tissue-implant interface is for dental abutment with mucosal contact. This shows that testing of the interface quality could be the most relevant in controlled conditions, which mimic as possible the clinical applications, but consider variables being under the control of the evaluator.

Original languageEnglish
Pages (from-to)550-562
Number of pages13
JournalSCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
Volume18
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017
MoE publication typeA2 Review article in a scientific journal

Keywords

  • Biomaterial
  • biomechanics
  • dynamics
  • implant
  • in vitro
  • simulation
  • testing

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