Ultrasonic transport of particles into articular cartilage and subchondral bone

H. J. Nieminen; T. Herranen; V. Kananen; S. A. Hacking; A. Salmi; P. Karppinen; E. Haeggstrom

doi:10.1109/ULTSYM.2012.0469

Ultrasonic transport of particles into articular cartilage and subchondral bone

H. J. Nieminen
, T. Herranen
, V. Kananen
, S. A. Hacking
, A. Salmi
, P. Karppinen
, E. Haeggstrom

Not published at Aalto University

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

9 Citations (Scopus)

Abstract

Osteoarthritis (OA) is a debilitating musculoskeletal disease without a cure. Delivery of therapeutic compounds is a problem and localized drug therapy could enable new treatment strategies. In this study high-intensity ultrasound was used to deliver micro-and nano-particles (MNPS) into three bovine osteochondral samples: (1) control (C) that was exposed to the particles without sonication, (2) UST-1 that was sonicated prior to immersion in a MNPS and (3) UST-2 that was sonicated in the presence of MNPS. Following treatment samples were cut into 2.9 ± 0.3 mm sections and digital images were obtained by light microscopy. In the sonicated samples (UST-1 and UST-2) MNPS penetrated into articular cartilage and subchondral bone. No MNPS penetration was observed in C. The proposed technique could potentially be used for local drug treatment of OA.

Original language	English
Title of host publication	2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages	1869-1872
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2012.0469
Publication status	Published - 2012
MoE publication type	A4 Conference publication
Event	IEEE International Ultrasonics Symposium - Dresden, Germany Duration: 7 Oct 2012 → 10 Oct 2012

Publication series

Name	IEEE International Ultrasonics Symposium
Publisher	IEEE
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	IEEE International Ultrasonics Symposium
Abbreviated title	IUS
Country/Territory	Germany
City	Dresden
Period	07/10/2012 → 10/10/2012

Funding

JDC, MMF, CMF and JFNG are members of RETIC (Thematic Networks of Corporate Research)/REDinREN (Kidney Disease Research Network)/RD16/0009/0022, (ISCIII – Carlos III Health Institute) and GEENDIAB (Diabetic Nephropathy Working Group of the Spanish Society of Nephrology). The research activity of JDC, EMN and JFNG is funded by the ISCIII (CD16/00165, FI14/00033 and INT15/00004, respectively). This study has been partly funded by research grants from the Spanish Society of Nephrology (SEN) and the Scientific Association for Nephrology Research (ACINEF) .

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10.1109/ULTSYM.2012.0469

Cite this

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title = "Ultrasonic transport of particles into articular cartilage and subchondral bone",

abstract = "Osteoarthritis (OA) is a debilitating musculoskeletal disease without a cure. Delivery of therapeutic compounds is a problem and localized drug therapy could enable new treatment strategies. In this study high-intensity ultrasound was used to deliver micro-and nano-particles (MNPS) into three bovine osteochondral samples: (1) control (C) that was exposed to the particles without sonication, (2) UST-1 that was sonicated prior to immersion in a MNPS and (3) UST-2 that was sonicated in the presence of MNPS. Following treatment samples were cut into 2.9 ± 0.3 mm sections and digital images were obtained by light microscopy. In the sonicated samples (UST-1 and UST-2) MNPS penetrated into articular cartilage and subchondral bone. No MNPS penetration was observed in C. The proposed technique could potentially be used for local drug treatment of OA.",

author = "Nieminen, \{H. J.\} and T. Herranen and V. Kananen and Hacking, \{S. A.\} and A. Salmi and P. Karppinen and E. Haeggstrom",

note = "Funding Information: JDC, MMF, CMF and JFNG are members of RETIC (Thematic Networks of Corporate Research)/REDinREN (Kidney Disease Research Network)/RD16/0009/0022, (ISCIII – Carlos III Health Institute) and GEENDIAB (Diabetic Nephropathy Working Group of the Spanish Society of Nephrology). The research activity of JDC, EMN and JFNG is funded by the ISCIII (CD16/00165, FI14/00033 and INT15/00004, respectively). This study has been partly funded by research grants from the Spanish Society of Nephrology (SEN) and the Scientific Association for Nephrology Research (ACINEF) . ; IEEE International Ultrasonics Symposium, IUS ; Conference date: 07-10-2012 Through 10-10-2012",

year = "2012",

doi = "10.1109/ULTSYM.2012.0469",

language = "English",

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series = "IEEE International Ultrasonics Symposium",

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Nieminen, HJ, Herranen, T, Kananen, V, Hacking, SA, Salmi, A, Karppinen, P & Haeggstrom, E 2012, Ultrasonic transport of particles into articular cartilage and subchondral bone. in 2012 IEEE International Ultrasonics Symposium, IUS 2012., 6562164, IEEE International Ultrasonics Symposium, pp. 1869-1872, IEEE International Ultrasonics Symposium, Dresden, Germany, 07/10/2012. https://doi.org/10.1109/ULTSYM.2012.0469

Ultrasonic transport of particles into articular cartilage and subchondral bone. / Nieminen, H. J.; Herranen, T.; Kananen, V. et al.
2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 1869-1872 6562164 (IEEE International Ultrasonics Symposium).

Research output: Chapter in Book/Report/Conference proceeding › Conference article in proceedings › Scientific › peer-review

TY - GEN

T1 - Ultrasonic transport of particles into articular cartilage and subchondral bone

AU - Nieminen, H. J.

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AU - Hacking, S. A.

AU - Salmi, A.

AU - Karppinen, P.

AU - Haeggstrom, E.

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PY - 2012

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N2 - Osteoarthritis (OA) is a debilitating musculoskeletal disease without a cure. Delivery of therapeutic compounds is a problem and localized drug therapy could enable new treatment strategies. In this study high-intensity ultrasound was used to deliver micro-and nano-particles (MNPS) into three bovine osteochondral samples: (1) control (C) that was exposed to the particles without sonication, (2) UST-1 that was sonicated prior to immersion in a MNPS and (3) UST-2 that was sonicated in the presence of MNPS. Following treatment samples were cut into 2.9 ± 0.3 mm sections and digital images were obtained by light microscopy. In the sonicated samples (UST-1 and UST-2) MNPS penetrated into articular cartilage and subchondral bone. No MNPS penetration was observed in C. The proposed technique could potentially be used for local drug treatment of OA.

AB - Osteoarthritis (OA) is a debilitating musculoskeletal disease without a cure. Delivery of therapeutic compounds is a problem and localized drug therapy could enable new treatment strategies. In this study high-intensity ultrasound was used to deliver micro-and nano-particles (MNPS) into three bovine osteochondral samples: (1) control (C) that was exposed to the particles without sonication, (2) UST-1 that was sonicated prior to immersion in a MNPS and (3) UST-2 that was sonicated in the presence of MNPS. Following treatment samples were cut into 2.9 ± 0.3 mm sections and digital images were obtained by light microscopy. In the sonicated samples (UST-1 and UST-2) MNPS penetrated into articular cartilage and subchondral bone. No MNPS penetration was observed in C. The proposed technique could potentially be used for local drug treatment of OA.

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DO - 10.1109/ULTSYM.2012.0469

M3 - Conference article in proceedings

AN - SCOPUS:84882324360

SN - 9781467345613

T3 - IEEE International Ultrasonics Symposium

SP - 1869

EP - 1872

BT - 2012 IEEE International Ultrasonics Symposium, IUS 2012

T2 - IEEE International Ultrasonics Symposium

Y2 - 7 October 2012 through 10 October 2012

ER -

Ultrasonic transport of particles into articular cartilage and subchondral bone

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