Projects per year
Abstract
Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3–6× in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures.
Original language | English |
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Article number | 8234 |
Number of pages | 15 |
Journal | Scientific Reports |
Volume | 11 |
Issue number | 1 |
DOIs | |
Publication status | Published - Dec 2021 |
MoE publication type | A1 Journal article-refereed |
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Dive into the research topics of 'Ultrasonic actuation of a fine-needle improves biopsy yield'. Together they form a unique fingerprint.Projects
- 2 Finished
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USeFNB: Ultrasound-enhanced fine-needle biopsy (USeFNB): sound-tissue –interactions
Nieminen, H. (Principal investigator), Arif, M. (Project Member), Perra, E. (Project Member), Barreto, G. (Project Member), Hayward, N. (Project Member), Ehnholm, G. (Project Member) & Nallannan, B. (Project Member)
01/09/2017 → 30/08/2020
Project: Academy of Finland: Other research funding
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USeFNB: Ultrasound-enhanced fine-needle biopsy: sound-tissue interactions
Nieminen, H. (Principal investigator), Le Bourlout, Y. (Project Member), Perra, E. (Project Member), Ehnholm, G. (Project Member), Rantanen, J. (Project Member), Kiviluoto, J. (Project Member), Rehell, M. (Project Member) & Fauconnier, M. (Project Member)
01/09/2017 → 15/09/2023
Project: Academy of Finland: Other research funding
Press/Media
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21st century medical needles for high-tech cancer diagnostics
21/04/2021 → 25/04/2021
9 items of Media coverage
Press/Media: Media appearance