Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities

Manuel Hartweg; Charlotte J.C. Edwards-Gayle; Elham Radvar; Dominic Collis; Mehedi Reza; Michael Kaupp; Jan Steinkoenig; Janne Ruokolainen; Robert Rambo; Christopher Barner-Kowollik; Ian W. Hamley; Helena S. Azevedo; C. Remzi Becer

doi:10.1039/c7py01953j

Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities

Research output: Contribution to journal › Article › Scientific › peer-review

Standard

Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities. / Hartweg, Manuel; Edwards-Gayle, Charlotte J.C.; Radvar, Elham; Collis, Dominic; Reza, Mehedi; Kaupp, Michael; Steinkoenig, Jan; Ruokolainen, Janne; Rambo, Robert; Barner-Kowollik, Christopher; Hamley, Ian W.; Azevedo, Helena S.; Becer, C. Remzi.

In: Polymer Chemistry, Vol. 9, No. 4, 28.01.2018, p. 482-489.

Research output: Contribution to journal › Article › Scientific › peer-review

Harvard

Hartweg, M, Edwards-Gayle, CJC, Radvar, E, Collis, D, Reza, M, Kaupp, M, Steinkoenig, J, Ruokolainen, J, Rambo, R, Barner-Kowollik, C, Hamley, IW, Azevedo, HS & Becer, CR 2018, 'Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities', Polymer Chemistry, vol. 9, no. 4, pp. 482-489. https://doi.org/10.1039/c7py01953j

APA

Hartweg, M., Edwards-Gayle, C. J. C., Radvar, E., Collis, D., Reza, M., Kaupp, M., ... Becer, C. R. (2018). Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities. Polymer Chemistry, 9(4), 482-489. https://doi.org/10.1039/c7py01953j

Vancouver

Hartweg M, Edwards-Gayle CJC, Radvar E, Collis D, Reza M, Kaupp M et al. Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities. Polymer Chemistry. 2018 Jan 28;9(4):482-489. https://doi.org/10.1039/c7py01953j

Author

Hartweg, Manuel ; Edwards-Gayle, Charlotte J.C. ; Radvar, Elham ; Collis, Dominic ; Reza, Mehedi ; Kaupp, Michael ; Steinkoenig, Jan ; Ruokolainen, Janne ; Rambo, Robert ; Barner-Kowollik, Christopher ; Hamley, Ian W. ; Azevedo, Helena S. ; Becer, C. Remzi. / Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities. In: Polymer Chemistry. 2018 ; Vol. 9, No. 4. pp. 482-489.

Bibtex - Download

@article{234deea9302246e4b9f2703f98f0f88f,

title = "Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities",

abstract = "Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi multicomponent reaction has not yet been studied. Herein, we report a synthetic strategy that enables both the modification of peptides as well as the generation of sequence-defined peptide-peptoid hybrid structures. Our synthetic methodology rests on the fusion of solid phase peptide synthesis with Ugi multicomponent reactions. We evidence that a diversity of chemical functionalities can be inserted into peptides or used in the design of peptide-peptoid hybrids exploiting a wide functional array including amines, carboxylic acids, hydrocarbons, carbohydrates as well as polymers, introducing a sequence-defined synthetic platform technology for precision peptoid hybrids.",

author = "Manuel Hartweg and Edwards-Gayle, {Charlotte J.C.} and Elham Radvar and Dominic Collis and Mehedi Reza and Michael Kaupp and Jan Steinkoenig and Janne Ruokolainen and Robert Rambo and Christopher Barner-Kowollik and Hamley, {Ian W.} and Azevedo, {Helena S.} and Becer, {C. Remzi}",

year = "2018",

month = "1",

day = "28",

doi = "10.1039/c7py01953j",

language = "English",

volume = "9",

pages = "482--489",

journal = "Polymer Chemistry",

issn = "1759-9954",

publisher = "The Royal Society of Chemistry",

number = "4",

}

RIS - Download

TY - JOUR

T1 - Ugi multicomponent reaction to prepare peptide-peptoid hybrid structures with diverse chemical functionalities

AU - Hartweg, Manuel

AU - Edwards-Gayle, Charlotte J.C.

AU - Radvar, Elham

AU - Collis, Dominic

AU - Reza, Mehedi

AU - Kaupp, Michael

AU - Steinkoenig, Jan

AU - Ruokolainen, Janne

AU - Rambo, Robert

AU - Barner-Kowollik, Christopher

AU - Hamley, Ian W.

AU - Azevedo, Helena S.

AU - Becer, C. Remzi

PY - 2018/1/28

Y1 - 2018/1/28

N2 - Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi multicomponent reaction has not yet been studied. Herein, we report a synthetic strategy that enables both the modification of peptides as well as the generation of sequence-defined peptide-peptoid hybrid structures. Our synthetic methodology rests on the fusion of solid phase peptide synthesis with Ugi multicomponent reactions. We evidence that a diversity of chemical functionalities can be inserted into peptides or used in the design of peptide-peptoid hybrids exploiting a wide functional array including amines, carboxylic acids, hydrocarbons, carbohydrates as well as polymers, introducing a sequence-defined synthetic platform technology for precision peptoid hybrids.

AB - Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi multicomponent reaction has not yet been studied. Herein, we report a synthetic strategy that enables both the modification of peptides as well as the generation of sequence-defined peptide-peptoid hybrid structures. Our synthetic methodology rests on the fusion of solid phase peptide synthesis with Ugi multicomponent reactions. We evidence that a diversity of chemical functionalities can be inserted into peptides or used in the design of peptide-peptoid hybrids exploiting a wide functional array including amines, carboxylic acids, hydrocarbons, carbohydrates as well as polymers, introducing a sequence-defined synthetic platform technology for precision peptoid hybrids.

UR - http://www.scopus.com/inward/record.url?scp=85041112316&partnerID=8YFLogxK

U2 - 10.1039/c7py01953j

DO - 10.1039/c7py01953j

M3 - Article

VL - 9

SP - 482

EP - 489

JO - Polymer Chemistry

JF - Polymer Chemistry

SN - 1759-9954

IS - 4

ER -

ID: 17485470